Jeng-Fan Lo

Lo, Jeng-Fan, PhD


Institute of Oral Biology

College of Dentistry

National Yang Ming Chiao Tung University



Postdoctoral Fellow (The Scripps Research Institute, La Jolla, CA, USA)
Ph.D. (University of Illinois, Chicago, IL, USA)


Appointment Status
Distinguished Professor


Cancer Biology, Stem Cell Biology, Mouse Genetics and Molecular Immunology


Membership of Associated Professional Bodies
American Association for Cancer Research

Taiwan Society of Mitochondrial Research and Medicine

Taiwan Oncology Society


Publications (5-year, selected publications; *: corresponding author)


  1. Chen KY, Huang YH, Teo WH, Chang CW, Chen YS, Yeh YC Lee CJ and Lo JF*. Loss of Tid1/DNAJA3 Co-chaperone Promotes Progression and Recurrence of Hepatocellular Carcinoma after Surgical Resection: A Novel Model to Stratify Risk of Recurrence. Cancers (Basel). 2021 Jan 4, 13(1):138.
  2. Hung KF, Chen CY, Kawasumi M, Lan TY, Poon CL, Lin YS, Wu PJ, Chen YC, Chen BH, Wu CH, Lo JF, Weng RR and Sun YC. Adaptation to endoplasmic reticulum stress enhances resistance of oral cancer cells to cisplatin by up-regulating polymerase η and increasing DNA repair efficiency. Int J Mol Sci. 2020 December 31, 22(1):355.
  3. Teo WH, Lo JF*. Fann YN, Huang CY, Huang TF*. Ganoderma microsporum immunomodulatory protein, GMI, promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 Acetylation. Plos One. 2020 Dec 21, 15: e0244791.
  4. Wang SF, Huang KH, Tseng WC, Lo JF, Li AF, Fang WL, Chen CF, Yeh TS, Chang YL, Chou YC, Hung HH, Lee HC. DNAJA3/Tid1 Is Required for Mitochondrial DNA Maintenance and Regulates Migration and Invasion of Human Gastric Cancer Cells. Cancers (Basel). 2020 Nov 20;12(11):3463.
  5. Hung KF, Sun YC, Chen BH, Lo JF, Cheng CM, Chen CY, Wu CH, Kao SY. New COVID-19 saliva-based test: How good is it compared with the current nasopharyngeal or throat swab test? J Chin Med Assoc. 2020 Oct 1;83(10):891-894.
  6. Hu WC, Teo WH, Huang TF, Lee TC and Lo JF*. Combinatorial Low Dose Arsenic Trioxide and Cisplatin Exacerbates Autophagy via AMPK/STAT3 Signaling on Targeting Head and Neck Cancer Initiating Cells. Frontiers in Oncology. 2020 Apr 15; 10:463.
  7. Li WC, Huang CH, Shieh YT, Chen TY, Cheng LH, Chen CY, Liu CJ, Chen HM, Huang CL, Lo JF and Chang KW. Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis. Frontiers in Oncology. 2020 Mar 31; 10:410.
  8. Chen TY, Hsieh YT, Huang JM, Liu CJ, Chuang LT, Huang PC, Kuo TY, Chia HY, Chou CY, Chang CW, Chen YF, Chen HM, Lo JF, Li WC. Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis. Neoplasia. 2019 May 14;21(7):641-652.
  9. Chao CN, Lo JF, Khan FB, Day CH, Lai CH, Chen CH, Chen RJ, Viswanadha VP, Kuo CH, Huang CY. Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade. J Cell Biochem. 2019 May 13. doi: 10.1002/jcb.28928.
  10. Chao CN, Lai CH, Badrealam KF, Lo JF, Shen CY, Chen CH, Chen RJ, Viswanadha VP, Kuo WW, Huang CY. CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation. J Cell Physiol. 2019 Nov; 234(11):20128-20138.
  11. Chang CW, Lo JF, Wang X. Roles of Mitochondria in Liver Cancer Stem Cells. Differentiation. 2019; 107:35-41.
  12. Hung KF*, Liao PC, Chen CK, Chiu YT, Cheng DH, Kawasumi M, Kao SY, Lo JF*. ASB6 Promotes the Stemness Properties and Sustains Metastatic Potential of Oral Squamous Cell Carcinoma Cells by Attenuating ER Stress. Int J Biol Sci 2019;15(5):1080-1090.
  13. Feng CC, Liao PH, Tsai HI, Cheng SM, Yang LY, PadmaV, Pan LF, Chen RJ, Lo JF, Huang CY. Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs. Int J Med Sci 2018; 15(13):1537-1546.
  14. Chen YS, Chang CW, Tsay YG, Huang LY, Wu YC, Cheng LH, Yang CC, Wu CH, Teo WH, Hung KF, Huang CY, Lee TC and Lo JF*. The HSP40 Co-Chaperone Protein, Tid1 suppresses metastasis of head and neck cancer cells through the inhibition of Galectin-7-TCF3-MMP9 Axis Signaling. Theranostics, 2018 Jun 13;8(14):3841-3855.
  15. Chang CW, Chen YS, Tsay YG, Han CL, Chen YJ, Yang CC, Hung KF, Lin CH, Huang TY, Kao SY, Lee TC, Lo JF*. ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells. Cell Death Dis. 2018 Feb 7;9(2): 194.
  16. Cheng LH, Hung KF, Lee TC, Huang CY, Chiu WT, Huang TF, Lo JF*. Mitochondrial co-chaperone protein Tid1 is required for energy homeostasis during skeletal myogenesis. Stem Cell Res Ther. 2016 Dec 7;7(1):185.
  17. Huang CY, Kuo WW, Lo JF, Ho TJ, Pai PY, Chiang SF, Chen PY, Tsai FJ, Tsai CH, Huang CY. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11): e2455.
  18. Cheng LH, Hung KF, Huang TF, Hsieh HP, Wang SY, Huang CY, Lo JF*. Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers. Oncotarget. 2016 Oct 26. 12935.
  19. Chang CW, Chen YS, Chen CC, Chan IO, Chen CC, Sheu SJ, Lin TW, Chou SH, Liu CJ, Lee TC, Lo JF*. Targeting cancer initiating cells by promoting cell differentiation and restoring chemosensitivity via dual inactivation of STAT3 and src activity using an active component of antrodia cinnamomea mycelia. Oncotarget. 2016 Sep 22. 12194.
  20. Yeh DW, Chen YS, Lai CY, Liu YL, Lu CH, Lo JF, Chen L, Hsu LC, Luo Y, Xiang R and Chuang TH. Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells. Cell Death and Differentiation. 2016 May; 23(5): 841-52.


Book Chapters

  1. Teo WH., Fann YN., Lo JF*. DNAJA3, a Co-chaperone in Development and Tumorigenesis. In: Heat Shock Proteins. Springer, Dordrecht. First Online: 16 September 2020. Publisher Name; Springer, Dordrecht.


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