國立陽明交通大學牙醫學系

National Yang Ming Chiao Tung University Department of Dentistry

Shu-Chun LIN

Name
LIN Shu-Chun

Professor

Institute of Oral Biology

College of Dentistry

National Yang Ming Chiao Tung University

Qualifications
PhD (University of Illinois, USA)

MS (National Yang-Ming University, Taiwan)

BS (National Taiwan University, Taiwan)

 

Appointment Status
Professor

 

Discipline
Biochemistry, Tumor Biology, Molecular Biology

 

Membership of Associated Professional Bodies
American Association for Cancer Research

1996-1997: Postdoctoral fellowship, Academia Sinica, Taiwan

 

My current Scopus h-index score is 45. My lab investigates the mechanisms underlying the molecular pathogenesis of oral cancer. We welcome international students or scholars interested in oral cancer researches.

 

Publications (5-year)

  1. Chang, S.R.; Chou, C.H.; Liu, C.J.; Lin, Y.C.; Tu, H.F.; Chang, K.W.; Lin, S.C. The Concordant Disruption of B7/CD28 Immune Regulators Predicts the Prognosis of Oral Carcinomas. Int J Mol Sci 2023, 24, doi:10.3390/ijms24065931.
  2. Lin, S.C.; Liu, C.J.; Ji, S.H.; Hung, W.W.; Liu, Y.C.; Chang, S.R.; Tu, H.F.; Chang, K.W. The upregulation of oncogenic miRNAs in swabbed samples obtained from oral premalignant and malignant lesions. Clin Oral Investig 2022, 26, 1343-1351, doi:10.1007/s00784-021-04108-y.
  3. Chou, C.H.; Chiang, C.F.; Yang, C.C.; Liu, Y.C.; Chang, S.R.; Chang, K.W.; Lin, S.C. miR-31-NUMB Cascade Modulates Monocarboxylate Transporters to Increase Oncogenicity and Lactate Production of Oral Carcinoma Cells. Int J Mol Sci 2021, 22, doi:10.3390/ijms222111731.
  4. Chen, H.H.; Yu, H.I.; Rudy, R.; Lim, S.L.; Chen, Y.F.; Wu, S.H.; Lin, S.C.; Yang, M.H.; Tarn, W.Y. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience 2021, 24, 103086, doi:10.1016/j.isci.2021.103086.
  5. Chang, K.W.; Hung, W.W.; Chou, C.H.; Tu, H.F.; Chang, S.R.; Liu, Y.C.; Liu, C.J.; Lin, S.C. LncRNA MIR31HG Drives Oncogenicity by Inhibiting the Limb-Bud and Heart Development Gene (LBH) during Oral Carcinoma. Int J Mol Sci 2021, 22, doi:10.3390/ijms22168383.
  6. Yeh, L.Y.; Yang, C.C.; Wu, H.L.; Kao, S.Y.; Liu, C.J.; Chen, Y.F.; Lin, S.C.; Chang, K.W. The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma. Front Oncol 2020, 10, 47, doi:10.3389/fonc.2020.00047.
  7. Lin, S.C.; Wu, H.L.; Yeh, L.Y.; Yang, C.C.; Kao, S.Y.; Chang, K.W. Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells. Int J Mol Sci 2020, 21, doi:10.3390/ijms21249442.
  8. Chang, K.W.; Lin, C.E.; Tu, H.F.; Chung, H.Y.; Chen, Y.F.; Lin, S.C. Establishment of a p53 Null Murine Oral Carcinoma Cell Line and the Identification of Genetic Alterations Associated with This Carcinoma. Int J Mol Sci 2020, 21, doi:10.3390/ijms21249354.
  9. Kao, Y.Y.; Chou, C.H.; Yeh, L.Y.; Chen, Y.F.; Chang, K.W.; Liu, C.J.; Fan Chiang, C.Y.; Lin, S.C. MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. Cancer Lett 2019, 456, 40-48, doi:10.1016/j.canlet.2019.04.028.
  10. Chen, Y.F.; Wei, Y.Y.; Yang, C.C.; Liu, C.J.; Yeh, L.Y.; Chou, C.H.; Chang, K.W.; Lin, S.C. miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A. Redox Biol 2019, 22, 101140, doi:10.1016/j.redox.2019.101140.
  11. Chen, Y.F.; Liu, C.J.; Lin, L.H.; Chou, C.H.; Yeh, L.Y.; Lin, S.C.; Chang, K.W. Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models. BMC Cancer 2019, 19, 281, doi:10.1186/s12885-019-5486-7.
  12. Chen, Y.F.; Chang, K.W.; Yang, I.T.; Tu, H.F.; Lin, S.C. Establishment of syngeneic murine model for oral cancer therapy. Oral Oncol 2019, 95, 194-201, doi:10.1016/j.oraloncology.2019.06.026.
  13. Chou CH, Fan Chiang CY, Yang CC, Liu YC, Chang SR, Chang KW*, Lin SC* (2021). miR-31-NUMB cascade modulates monocarboxylate transporters to increase oncogenicity and lactate production of oral carcinoma cells. Int J Mol Sci, 22, 11731.
  14. Lin SC., Liu CJ, Ji SH, Hung WW, Liu YC, Chang SR, Tu HF, Chang KW* (2021). The upregulation of oncogenic miRNAs in swabbed samples obtained from oral premalignant and malignant lesions. Clin Oral Invest, 1-9.
  15. Chang KW, Hung WW, Chou CH, Tu HF, Chang SR, Liu YC, Liu CJ, Lin SC* (2021). LncRNA MIR31HG drives oncogenicity by inhibiting the Limb-Bud and Heart Development gene (LBH) during oral carcinoma. Int J Mol Sci, 21, 8383.
  16. Chang KW, Lin CE, Tu HF, Chung HY, Chen YF, Lin SC* (2020). Establishment of a p53 null murine oral carcinoma cell line and the identification of genetic alterations associated with this carcinoma. Int J Mol Sci, 2020, 21, 9354.
  17. Yeh LY, Yang CC, Wu HL, Kao SY, Liu CJ, Chen YF, Lin SC*, Chang KW* (2020). The miR-372-ZBTB7A oncogenic axis suppresses TRAIL-R2 associated drug sensitivity in oral carcinoma. Front Oncol, 10: 47
  18. Lin SC, Wu HL, Yeh LY, Yang CC, Kao SY, Chang KW* (2020). Activation of the miR-371/372/373 miRNA cluster enhances oncogenicity and drug resistance in oral carcinoma cells. Int J Mol Sci, 2020, 21, 9442.
  19. Chen YF, Chang KW, Yang IT, Tu HF, Lin SC* (2019). Establishment of syngeneic murine model for oral cancer therapy. Oral Oncol, 95: 194-201.
  20. Kao YY, Chen YF, Yeh LY, Chen YF, Chang KW, Liu CJ, Fan Chiang CY, Lin SC* (2019). MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. Cancer Letters, 456: 40-8.
  21. Chen YF, Liu CJ, Lin LH, Chou CH, Yeh LY, Lin SC*, Chang, KW* (2019). Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models. BMC Cancer, 19: 281.
  22. Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH, Chang KW*, Lin SC* (2019). miR-125b suppresses oral oncogenicity by targeting the antioxidative gene PRXL2A. Redox Biol, 22, 101140.
  23. Lin SC, Lin LH, Yu SY, Kao SY, Chang KW, Cheng HW, Liu CJ*. (2018). FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival. Carcinogenesis, 39 (11): 1320-30.
  24. Peng SY, Tu HF, Yang CC, Wu CH, Liu CJ, Chang KW*, Lin SC* (2018). miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. Int J Cancer, 143: 2892-2904.
  25. Chou CH, Tu HF, Kao SY, Fan Chiang C-Y, Liu CJ, Chang KW*, Lin SC* (2018). Targeting of miR-31/96/182 to the Numb gene during head and neck oncogenesis. Head and Neck, 40: 808-17.
  26. Wang MC, Yeh LY, Shih WY, Li WC, Chang KW*, Lin SC* (2018). Portland cement induces human periodontal ligament cells to differentiate by upregulating miR-146a. J Form Med Ass, 117 (4) 308-315.
  27. Liu CJ, Lin JS, Cheng HW, Hsu YH, Cheng CY, Lin SC* (2017). Plasma miR-187* is a potential biomarker for oral carcinoma. Clin Oral Invest, 21:1131-8.
  28. Lin SC, Kao SY, Chang J CY, Liu YJ, Yu EH, Tseng SH, Liu CJ*, Chang KW* (2016). Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor. Oncotarget, 7: 61355-65.
  29. Kao SY, Tsai MM, Wu CH, Chen JJ, Tseng SH, Lin SC*, Chang KW* (2016). Co-targeting of multiple microRNAs on factor-inhibiting hypoxia-inducible factor (FIH) gene for the pathogenesis of head and neck carcinomas. Head and Neck, 38(4): 522-8.
  30. Lu WC, Liu CJ, Tu HF, Chung YT, Yang CC, Kao SY, Chang KW*, Lin SC* (2016). miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma. Oncotarget, 7: 51002-16.
  31. Chen YF, Yang CC, Kao SY, Liu CJ, Lin SC*, Chang KW* (2016). MicroRNA-211 enhances the oncogenicity of carcinogen-induced oral carcinoma by repressing TCF12 and increasing antioxidant activity. Cancer Res, 76: 4872-86.

Contact
Email Address: shuchun@nycu.edu.tw