Shu-Chun LIN

LIN Shu-Chun


Institute of Oral Biology

College of Dentistry

National Yang Ming Chiao Tung University

PhD (University of Illinois, USA)

MS (National Yang-Ming University, Taiwan)

BS (National Taiwan University, Taiwan)


Appointment Status


Biochemistry, Tumor Biology, Molecular Biology


Membership of Associated Professional Bodies
American Association for Cancer Research

1996-1997: Postdoctoral fellowship, Academia Sinica, Taiwan

  1. Chou CH, Fan Chiang CY, Yang CC, Liu YC, Chang SR, Chang KW*, Lin SC* (2021). miR-31-NUMB cascade modulates monocarboxylate transporters to increase oncogenicity and lactate production of oral carcinoma cells. Int J Mol Sci, 22, 11731.
  2. Lin SC., Liu CJ, Ji SH, Hung WW, Liu YC, Chang SR, Tu HF, Chang KW* (2021). The upregulation of oncogenic miRNAs in swabbed samples obtained from oral premalignant and malignant lesions. Clin Oral Invest, 1-9.
  3. Chang KW, Hung WW, Chou CH, Tu HF, Chang SR, Liu YC, Liu CJ, Lin SC* (2021). LncRNA MIR31HG drives oncogenicity by inhibiting the Limb-Bud and Heart Development gene (LBH) during oral carcinoma. Int J Mol Sci, 21, 8383.
  4. Chang KW, Lin CE, Tu HF, Chung HY, Chen YF, Lin SC* (2020). Establishment of a p53 null murine oral carcinoma cell line and the identification of genetic alterations associated with this carcinoma. Int J Mol Sci, 2020, 21, 9354.
  5. Yeh LY, Yang CC, Wu HL, Kao SY, Liu CJ, Chen YF, Lin SC*, Chang KW* (2020). The miR-372-ZBTB7A oncogenic axis suppresses TRAIL-R2 associated drug sensitivity in oral carcinoma. Front Oncol, 10: 47
  6. Lin SC, Wu HL, Yeh LY, Yang CC, Kao SY, Chang KW* (2020). Activation of the miR-371/372/373 miRNA cluster enhances oncogenicity and drug resistance in oral carcinoma cells. Int J Mol Sci, 2020, 21, 9442.
  7. Chen YF, Chang KW, Yang IT, Tu HF, Lin SC* (2019). Establishment of syngeneic murine model for oral cancer therapy. Oral Oncol, 95: 194-201.
  8. Kao YY, Chen YF, Yeh LY, Chen YF, Chang KW, Liu CJ, Fan Chiang CY, Lin SC* (2019). MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. Cancer Letters, 456: 40-8.
  9. Chen YF, Liu CJ, Lin LH, Chou CH, Yeh LY, Lin SC*, Chang, KW* (2019). Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models. BMC Cancer, 19: 281.
  10. Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH, Chang KW*, Lin SC* (2019). miR-125b suppresses oral oncogenicity by targeting the antioxidative gene PRXL2A. Redox Biol, 22, 101140.
  11. Lin SC, Lin LH, Yu SY, Kao SY, Chang KW, Cheng HW, Liu CJ*. (2018). FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival. Carcinogenesis, 39 (11): 1320-30.
  12. Peng SY, Tu HF, Yang CC, Wu CH, Liu CJ, Chang KW*, Lin SC* (2018). miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. Int J Cancer, 143: 2892-2904.
  13. Chou CH, Tu HF, Kao SY, Fan Chiang C-Y, Liu CJ, Chang KW*, Lin SC* (2018). Targeting of miR-31/96/182 to the Numb gene during head and neck oncogenesis. Head and Neck, 40: 808-17.
  14. Wang MC, Yeh LY, Shih WY, Li WC, Chang KW*, Lin SC* (2018). Portland cement induces human periodontal ligament cells to differentiate by upregulating miR-146a. J Form Med Ass, 117 (4) 308-315.
  15. Liu CJ, Lin JS, Cheng HW, Hsu YH, Cheng CY, Lin SC* (2017). Plasma miR-187* is a potential biomarker for oral carcinoma. Clin Oral Invest, 21:1131-8.
  16. Lin SC, Kao SY, Chang J CY, Liu YJ, Yu EH, Tseng SH, Liu CJ*, Chang KW* (2016). Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor. Oncotarget, 7: 61355-65.
  17. Kao SY, Tsai MM, Wu CH, Chen JJ, Tseng SH, Lin SC*, Chang KW* (2016). Co-targeting of multiple microRNAs on factor-inhibiting hypoxia-inducible factor (FIH) gene for the pathogenesis of head and neck carcinomas. Head and Neck, 38(4): 522-8.
  18. Lu WC, Liu CJ, Tu HF, Chung YT, Yang CC, Kao SY, Chang KW*, Lin SC* (2016). miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma. Oncotarget, 7: 51002-16.
  19. Chen YF, Yang CC, Kao SY, Liu CJ, Lin SC*, Chang KW* (2016). MicroRNA-211 enhances the oncogenicity of carcinogen-induced oral carcinoma by repressing TCF12 and increasing antioxidant activity. Cancer Res, 76: 4872-86.

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