Cheng-Hsien Wu

Cheng-Hsien Wu

DDS (Taiwan, R.O.C.)
PhD (Taiwan, R.O.C.)
Board Certificate in Oral and Maxillofacial Surgery (Taiwan, R.O.C.)

Appointment Status
Associate Professor

Oral and Maxillofacial Surgery

Membership of Associated Professional Bodies
Taiwanese Association of Oral and Maxillofacial Surgery
Asian Association of Oral and Maxillofacial Surgeons
European Association for Craniomaxillofacial Surgery
Arbeitsgemeinschaft für Osteosynthesefragen-Cranio-Maxillofaical Specialty

Research Interests
Computer-assisted surgery (3D printing and navigation)
Head and neck oncology
Craniofacial deformity / orthognathic surgery
Facial traumatology
Minimally invasive maxillofacial surgery

2018 Medical Innovation Award, 3rd place (Taipei Veterans General Hospital, Taiwan, R.O.C.)
2017 Excellent Clinical Teaching Award (Veterans Affairs Council, Taiwan, R.O.C.)
2013-2017 Best Teaching Award (Taipei Veterans General Hospital, Taiwan, R.O.C.)


  1. Yang-Sung Lin, Wu CH, Chun-Li Lin. Novel multi-axial alveolar distractor – Part I: Design, manufacture and mechanical functional tests. J Cranio Maxillofac Surg 2019 (Accept).
  2. Chen YS, Chang KW, Tsay YG, Huang LY, Wu YC, Cheng LH, Yang CC, Wu CH, Teo WH, Hung KF, Huang CY, Lee TC, Lo JF. HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3 – MMP9 axis signaling. Theranostics 2018 Jun 13;8(14):3841-3855.
  3. Peng SY, Tu HF, Yang CC, Wu CH, Liu CJ, Chang KW, Lin SC. miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. Int J Cancer 2018 Dec 1;143(11):2892-2904.
  4. Yang HY, Wu CH, Tsai CC, Yu WK, Kao SC, Liu CJ. Primary ductal adenocarcinoma of lacrimal gland: Two case reports and review of the literature. Taiwan J Ophthalmol 2018 Jan-Mar;8(1):42-48.
  5. Wu CH, Lin YS, Liu YS, Lin CL. Biomechanical evaluation of a novel hybrid reconstruction plate for mandible segmental defects: a finite element analysis and fatigue testing. J Cranio Maxillofac Surg 2017 Oct;45(10):1671-1680.
  6. Lim E, Wu CH, Moi SH, Lui MT, Yang CH, Yang CC. The expression of transglutaminase 2 (TG-2) in oral squamous cell carcinoma and its clinical significance. J Chin Med Assoc 2017 Aug;80(8):515-520.
  7. Lai TY, Hu YW, Liu YM, Chen YW, Shiau CY, Chu PY, Tai SK, Lo WL, Wu CH, Wang LW. The pattern of failure and predictors of locoregional control in lateralized buccogingival cancer after postoperative radiation therapy. J Chin Med Assoc 2017 Sep;80(9):569-574.
  8. Yu EH, Tu HF, Wu CH, Yang CC, Chang KW. MicroRNA-21 promotes perineural invasion and impacts survival in patients with oral carcinoma. J Chin Med Assoc 2017 Jun;80(6):383-388.
  9. Yang CC, Tu HF, Wu CH, Chang HC, Chiang WF, Shih NC, Lee YS, Kao SY, Chang KW. Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC. Oral Oncol 2016 May;56:54-61.
  10. Kao SY, Tsai MM, Wu CH, Chen JJ, Tseng SH, Lin SC, Chang KW. Co-targeting of multiple microRNAs on factor inhibiting hypoxia-inducible factor (FIH) gene for the pathogenesis of head and neck carcinomas. Head Neck 2016 Apr;38(4):522-8.
  11. Lu WC, Kao SY, Yang CC, Wu CH, Chang KW, Lin SC. EGF up-regulates miR-31 through the C/EBPß signal cascade in oral carcinoma. PLoS One 2014 Sep 17;9(9): e108049.
  12. Yu EH, Lui MT, Tu HF, Wu CH, Lo WL, Yang CC, Chang KW, Kao SY. Oral carcinoma with perineural invasion has higher nerve growth factor expression and worse prognosis. Oral Dis 2014 Apr;20(3):268-74.
  13. Chang KW, Chu TH, Gong NR, Chiang WF, Yang CC, Liu CJ, Wu CH, Lin SC. miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma. Oral Dis 2013 Sep; 19(6):611-9.
  14. Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH. Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature. Eur Arch Otorhinolaryngol 2011;268(7):1035-40.
  15. Wu CH, Wu TY, Li CG, Lui MT, Chang KW, Kao SY: Impact of diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma: a retrospective cohort study. Ann Surg Oncol 2010;17(8):2175-83.
  16. Chiu YW, TU HF, Wang IK, Wu CH, Chang KW, Liu TY, Kao SY: The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis. Oral Oncol 2010;46(4):302-6.
  17. Chen YW, Wu CH*: A rare complication of acquired factor VIII inhibitors in a post-operative oral cancer patient- a case report. J Oral Maxillofac Surg 2010 Aug;68(8):1989-93.
  18. Kao SY, Chen YP, Tu HF, Liu CJ, Yu AH, Wu CH, Chang KW: Nuclear STK15 expression is associated with aggressive behavior of oral carcinoma cells in vivo and in vitro. J Pathol 2010 Sep;222(1):99-109.
  19. Su PF, Huang WL, Wu HT, Wu CH, Liu TY, Kao SY. p16(INK4A) promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner. Oral Oncol 2010 Oct;46(10):734-9.
  20. Wu CH, Tu HF, Gong NR, Chen YW, Liu CJ, Kao SY: The Val allele of HER-2 codon 655 predicts the progression of oral squamous cell carcinoma. Oral Oncol 2009;45(7):579-83.
  21. Wu TY, Kuang SH, Wu CH*: Factors associated with the stability of mini-implants for orthodontic anchorage: a study of 414 samples in Taiwan. J Oral Maxillofac Surg 2009 Aug;67(8):1595-9.
  22. Wu TY, Yang SF, Kuang SH, Wu CH*: Treatment of a child with four congenitally missing maxillary premolars by auto-transplantation and orthodontic intervention: a case report. J Oral Maxillofac Surg 2009 Feb;67(2):450-6.
  23. Chen YW, Yu EH, Wu CH, Lo WL, Li WY, Kao SY: Histopathological factors affecting nodal metastasis in tongue cancer: analysis of 94 patients in Taiwan. Int J Oral Maxillofac Surg 2008;37:912-6.
  24. Hung PS, Kao SY, Liu CJ, Tu HF, Wu CH, Lin SC: Insulin-like growth factor binding protein-5 enhances the migration and differentiation of gingival epithelial cells. J Periodont Res 2008;43:673-80.
  25. Chen YW, Tu HF, Wu CH, Lo WL, Chang CS, Chang KW, Kao SY: Sarcomas and sarcomatoid tumor after radiotherapy of oral squamous cell carcinoma: Analysis of cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:65-71.
  26. Tu HF, Wu CH, Kao SY, Liu CJ, Chang KW, Wei YR, Lui MT: Functional -1562 C to T polymorphism in matrix metalloproteinase-9 (MMP-9) promoter is associated with the risk for oral squamous cell carcinoma in younger male areca users. J Oral Pathol Med 2007; 36: 409-14
  27. Chen YW, Lin JS, Wu CH, Lui MT, Kao SY, Fong Y: Application of in vivo stain of methylene blue as a diagnostic aid in the early detection and screening of oral squamous cell carcinoma and precancer lesions. J Chin Med Assoc 2007;70:497-503
  28. Chou SJ, Wu CH, Kao SY, Chang CS: Spindle cell carcinoma in the oral cavity. Asian J Oral Maxillofac Surg 2007;19:170-5
  29. Kao SY, Fong HJ, Chou SJ, Wu CH, Tu HF, Yeung TC. Segmental osteotomy to reposition multiple osseointegrated implants in the anterior maxilla in a trauma patient. Dental Traumatology 2007; 23: 56-59
  30. Chen YW, Lin JS, Fong Jenny HJ, Wong YK, Chou SJ, Wu CH, Lui MT, Chang CS, Kao SY : The Application of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions. British J Oral Maxillofacial Surg 2007;45:590-91
  31. Fong HJ, Lui MT, Wu CH, Chou IC, Yeung TC, Kao SY. Using distraction osteogenesis for repositioning the multiple dental implants retained premaxilla with autogenous bone graft and keratinized palatal mucosa graft vestibuloplasty in a trauma patient-report of a case. J Oral Maxillofac Surg 2006; 64: 794-798
  32. Yu EH, Lui MT, Chou SJ, Wang SJ, Hung KF, Lo WL, Chang CS, Wu CH*, Kao SY: Comparison of positron emission tomography and computed tomography for the detection of cervical lymph node metastases of oral squamous cell carcinoma. Asian J Oral Maxillofacial Surg 2006; 18:109-115
  33. Kao SY, Lui MT, Fong HJ, Wu CW, Wu CH, Tu HF, Feng HK, Yeung TC. A method using vestibule-sulcoplasty simultaneously combing split-thickness skin graft and palatal keratinized mucosa graft for rehabilitation of peri-implant tissue in the severely atrophic edentulous ridge secondary to oral cancer surgery. J Oral Implantol 2005; 31(4); 186-192.
  34. Kao SY, Fong HJ, Chou SJ, Wu CH, Tu HF, Yeung TC. Segmental osteotomy to reposition multiple osseointegrated dental implants in the anterior maxilla in a trauma patient. Dental Traumatology 2005; 21: 1-4.
  35. Kao SY, Fong HJ, Lui MT, Chou SJ, Yeung TC, Hung KF, Wu CH, Yu EH, Chang CS. Implant rehabilitation of severely traumatized anterior alveolar ridge. Asian J Oral Maxillofac Surg 2005; 17(4): 240-246.
  36. Wu CH, Tu HF, Chang CS, Kao SY. Antisense oligonucleotide therapy for oral squamous cell carcinoma in nude mice model. Asian J Oral Maxillofac Surg 2004; 16: 112-118
  37. Kao SY, Yeung TC, Hung KF, Chou IC, Wu CH, Chang CS: Transposition flap vestibuloplasty combined with implant surgery in the severely resorbed atrphic edentulous ridge. J Oral Implantol 28 (4): 194-199, 2002.
  38. Kao SY, Yeung TC, Lo WL, Wu CH, Lui MT, Richard Chang CS: Rehabilitation of Dental Implants for the Post-irradiated and Marginally Resected Mandible in an Oral Cancer Patient. Chin Med J 65: 548-552, 2002.
  39. Yang CC, Tu HF, Wu CH, Richard Chang CS, Kao SY: In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis. Chin Med J 65: 600-607, 2002.
  40. Kao SY, Wu CH, Lin SC, Yap SK, Chang CS, Wong YK, Chi LY, Liu TY: Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use. J Oral Pathol Med 31: 505-11, 2002.

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