林宥成 助理教授

【簡介】

本實驗室遊走於機器學習、基因體、與口腔醫學的交界,但基本上我們每天做的就是把咖啡轉換成程式 碼 :p

我們相信生物學的本質是「小」的科學,因此我們採行軟體設計的敏捷開發,整合「乾、濕」實驗,挖 掘生物新知

【研究方向】

癌症基因體學、精準醫療

【專長】

生物資訊、機器學習、基因體學、微生物學、遺傳學

【學歷】

畢業學校國別主修系別學位畢業年度
哥倫比亞大學美國生物學系博士2018
國立台灣大學台灣微生物與生化學研究所碩士2010
國立台灣大學台灣牙醫學系學士2008

【經歷】

服務單位服務部門職稱服務期間
LifeMine Therapeutics資料科學部門 – 基因體組資深計算生物學研究員2019 – 2021
新英格蘭實驗室研究部門博士後研究員2018 – 2019

【著作】

1.        Wang B, Lin Y-C, Vasquez-Rifo A, Jo J, Price-Whelan A, McDonald ST, Brown LM, Sieben C & Dietrich LEP (2021) Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence. Nature Communications, 12(1): 4613.

2.        Chen J-L, Lin Y-C, Fu H-Y & Yang C-S (2019) The blue-green sensory rhodopsin SRM from Haloarcula marismortui attenuates both phototactic responses mediated by sensory rhodopsin I and II in Halobacterium salinarum. Scientific Reports, 9(1): 5672.

3.        Choi PH, Jo J, Lin Y-C, Lin M-H, Chou C-Y, Dietrich LEP & Tong L (2016) A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nature Communications, 7: 12713.

4.        Fong JC, Rogers A, Michael AK, Parsley NC, Cornell W-C, Lin Y-C, Singh PK, Hartmann R, Drescher K, Vinogradov E, Dietrich LE, Partch CL & Yildiz FH (2017) Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms. ELife, 6.

5.        Fu H-Y, Lin Y-C, Chang Y-N, Tseng H, Huang C-C, Liu K-C, Huang C-S, Su C-W, Weng RR, Lee Y-Y, Ng WV & Yang C-S (2010) A novel six-rhodopsin system in a single archaeon. Journal of Bacteriology, 192(22): 5866– 5873.

6.        Hölscher T, Bartels B, Lin Y-C, Gallegos-Monterrosa R, Price-Whelan A, Kolter R, Dietrich LEP & Kovács ÁT (2015) Motility, chemotaxis and aerotaxis contribute to competitiveness during bacterial pellicle biofilm development. Journal of Molecular Biology, 427(23): 3695–3708.

7.        Lin Y-C, Cornell WC, Jo J, Price-Whelan A & Dietrich LEP (2018) The Pseudomonas aeruginosa Complement

of Lactate Dehydrogenases Enables Use of d- and l-Lactate and Metabolic Cross-Feeding. MBio, 9(5).

8.        Lin Y-C, Fu H-Y & Yang C-S (2010) Phototaxis of Haloarcula marismortui revealed through a novel microbial motion analysis algorithm. Photochemistry and Photobiology, 86(5): 1084–1090.

9.        Lin Y-C, Sekedat MD, Cornell WC, Silva GM, Okegbe C, Price-Whelan A, Vogel C & Dietrich LEP (2018) Phenazines Regulate Nap-Dependent Denitrification in Pseudomonas aeruginosa Biofilms. Journal of Bacteriology, 200(9).

10.    Madsen JS, Lin Y-C, Squyres GR, Price-Whelan A, de Santiago Torio A, Song A, Cornell WC, Sørensen SJ,Xavier JB & Dietrich LEP (2015) Facultative control of matrix production optimizes competitive fitness in Pseudomonas aeruginosa PA14 biofilm models. Applied and Environmental Microbiology, 81(24): 8414– 8426.

電子郵件:ylin@nycu.edu.tw