國立陽明交通大學牙醫學系

National Yang Ming Chiao Tung University Department of Dentistry

陳恆理 副教授(Hen-Li Chen, DDS, MS, PhD)

學歷：

畢業學校國別主修系別學位
密西根大學美國口腔健康科學博士
密西根大學美國牙周病學碩士
密西根大學美國牙周病學專科訓練
國立陽明大學中華民國牙醫學系學士

經歷：

服務單位職稱
國立陽明大學牙醫學系副教授
台北榮總牙科部牙周病科總醫師
國立陽明大學牙醫學系助理教授
台北榮總牙科部臨床研究員
專長：牙周病學、組織工程、基因治療、抗菌胜肽、再生治療
現職：國立陽明大學牙醫系副教授
聯絡電話：(02)2826-7314
電子郵件：henlichen@nycu.edu.tw

研究計畫

年度計畫名稱類型執行期間經費提供單位
2018植體表面去毒性模型及骨再整合之體外研究個人2018/08/01-2019/07/31科技部
2017應用人類防禦素以處理植體周圍炎相關之植體細菌汙染個人2017/08/01-2018/10/31科技部
2016長期低氧培養對人類牙周韌帶幹細胞的影響個人2016/08/01-2017/07/31科技部
2014探討防禦素對人類骨髓幹細胞的影響個人2014/01/01- 2014/12/31慶齡基金會
2013應用防禦素治療骨及牙周組織細菌感染之先期研究個人2013/09/01- 2013/12/15陽明大學
2012應用防禦素抗菌基因療法於感染骨及牙周缺損之再生治療個人2012/08/01-2013/07/31國科會
2012應用防禦素基因治療於細菌感染骨缺損治療共同2012/01/01- 2012/12/31台北榮總
2011人類beta-defensin 2 抗菌基因治療於骨工程之應用個人2011/09/01- 2011/12/15陽明大學
2010應用防禦素基因治療於細菌感染骨再生之前期研究共同2010/01/01- 2010/12/31台北榮總
2009應用組織工程及基因治療組合技術於齒槽嵴增高術共同2009/01/01-2009/12/31台北榮總
2004應用副甲狀腺素之骨再生研究個人2004/01/01-2008/12/31國家衛生院
2008擴增齒槽骨脊之前期研究- 建立狗骨髓間葉幹細胞培養及慢病毒基因治療系統共同2008/01/01-2008/12/31台北榮總
2007骨內給予骨成形蛋白四對人工植牙的影響個人2007/08/01-2008/07/31國科會
2007以組織工程重建齒槽骨脊之前期研究共同2007/01/01-2007/12/31台北榮總

SCI期刊論文(*通訊作者)

  1. K.H. Chien, Y.L. Chang, M.L. Wang, J H. Chuang, Y.C. Yang, M.C. Tai, C.Y. Wang, Y.Y. Liu, H.Y. Li, J.T. Chen, S.Y. Kao, H.L. Chen, W.L. Lo*. Promoting induced pluripotent stem cell-driven biomineralization and periodontal regeneration in rats with maxillary-molar defects using injectable BMP-6 hydrogel. Scientific Reports. 2018; 8(1):114.
  2. P.H. Lee, T.L. Yew, Y.L. Lai, S.Y. Lee, H.L Chen*. Parathyroid hormone gene-activated matrix with DFDBA/collagen composite matrix enhances bone regeneration in rat calvarial bone defects. Journal of the Chinese Medical Association. 2018; 81(8):699-707
  3. P.H. Lee, M.Y. Chen, Y.L. Lai, S.Y. Lee, and H.L. Chen*. Human beta-defensin-2 and -3 mitigate the negative effects of bacterial contamination on bone healing in rat calvarial defect. Tissue Engineering Part A. 2018; 24(7-8):653-61.
  4. W.H. Huang, H.L. Chen, P.H. Huang, T.L. Yew, M.W. Lin, S.J. Lin, S.C. Hung*. Hypoxic mesenchymal stem cells engraft and ameliorate limb ischaemia in allogeneic recipients. Cardiovascular Research. 2014; 101(2):266-76.
  5. Y. Chien, Y.W. Liao, D.M. Liu, H.L. Lin, S.J. Chen, H.L. Chen, C.H. Peng, C.M. Liang, C.Y. Mou, S.H. Chiou*. Corneal repair by human corneal keratocyte-reprogrammed iPSCs and amphiphatic carboxymethyl-hexanoyl chitosan hydrogel. Biomaterials. 2012; 33(32):8003-16.
  6. H.M. Chang, Y.W. Liao, C.H. Chiang, Y.J. Chen, Y.H. Lai, Y.L. Chang, H.L. Chen, S.Y. Jeng, J.H. Hsieh, C.H. Peng, H.Y. Li, Y. Chien*, S.Y. Chen, L.K. Chen, T.I. Huo*. Improvement of carbon tetrachloride-induced acute hepatic failure by transplantation of induced pluripotent stem cells without reprogramming factor c-Myc. International Journal of Molecular Sciences. 2012; 13(3):3598-617.
  7. Y.L. Lai, N.J. Kuo, W.K. Hsiao, T.L. Yew, S.Y. Lee, H.L. Chen*. Intramarrow bone morphogenetic protein 4 gene delivery enhances early implant stability in femurs of ovariectomized rabbits. Journal of Periodontology 2011; 82(7):1043-50.
  8. T.L. Yew, F.Y. Chiu, C.C. Tsai, H.L. Chen, W.P. Lee, Y.J. Chen, M.C. Chang, S.C. Hung*. Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells. Aging Cell 2011; 21(2):349-61.
  9. T.L. Yew, Y.T. Hung, H.Y. Li, H.W. Chen, L.L. Chen, K.S. Tsai, S.H. Chiou, K.C. Chao, H.L. Chen*, T.F. Huang, S.C. Hung*. Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38MAPK activation. Cell Transplantation 2011;20(5):693-706.
  10. W.K. Hsiao, T.L. Yew, Y.L. Lai, S.Y. Lee, and H.L. Chen*. Intramarrow BMP4 gene delivery improves local bone quality in femurs of ovariectomized rabbits. Journal of Periodontology 2011; 82(6):854-62.
  11. Y.L. Lai, H.L. Chen, L.Y. Chang, S.Y. Lee*. Resubmergence technique for the management of soft tissue recession around an Implant: Case report. International Journal of Oral & Maxillofacial Implants 2010; 25(1):201-4.
  12. D.C. Chen, Y.L. Lai, S.Y. Lee, S.L. Huang and H.L. Chen*. Osteoblastic response to collagen scaffolds varied in freezing temperature and glutaraldehyde crosslinking. Journal of Biomedical Materials Research Part A 2007; 80(2):399-409.
  13. Y.L. Lai, I.C. Chou, Y.C. Liaw, H.L. Chen, Y.C. Lin and S.Y. Lee*. Triple immediate therapy (ridge expansion, soft-tissue augmentation, and provisional restoration) of maxillary anterior single implant: A case report. Journal of Periodontology 2007; 78(7):1348-53.
  14. H.L. Chen, E.P. Frankenburg, S.A. Goldstein, L.K. McCauley*. The combination of local and systemic parathyroid hormone enhances bone regeneration. Clinical Orthopaedics and Related Research 2003; 416:291-302.
  15. D.C. Chen, Y.L.  Lai, H.L. Chen, S.Y. Lee*. Effect of circumferential undercut placement in the root canal wall on the retention of a tapered post in large and small root canals. Journal of Dentistry 2003; 31(4):247-52.
  16. H. Chen, B. Demiralp, A. Schneider, A.J. Koh, C. Silve, C.Y. Wang, L.K. McCauley*. Parathyroid hormone and parathyroid hormone related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. Journal of Biological Chemistry 2002; 277(22):19374-81.
  17. H. Chen, L.K. McCauley, N.J. D’Silva*. cAMP binding protein assay for widespread use in cell signaling studies. Biotechniques 2002;33(1):66-72.
  18. B. Demiralp, H. Chen, A.J. Koh, E.T. Keller, L.K. McCauley*. Anabolic actions of parathyroid hormone during bone growth are dependent on c-fos. Endocrinology 2002; 143(10):4038-47.
  19. L.K. McCauley, A.J. Koh-Paige, H. Chen, C. Chen, C. Ontiveros, R. Irwin, L.R. McCabe*: Parathyroid hormone stimulates fra-2 expression in osteoblastic cells in vitro and in vivo. Endocrinology 2001; 142(5):1975-81.