國立陽明交通大學牙醫學系

National Yang Ming Chiao Tung University Department of Dentistry

涂曦丰 副教授 (Tu, Hsi-Feng)

學歷：

畢/肄業學校主修系別學位學位畢業年度
國立陽明大學口腔生物研究所博士2011
國立陽明大學臨床牙醫學研究所碩士2002
台北醫學大學牙醫學系學士1998

經歷：

服務單位服務部門職稱服務期間起
國立陽明交通大學附設醫院　牙科部部主任2014/12/19~
國立陽明大學　牙醫學系副教授　2013/08/01~　
國立陽明大學　牙醫學系助理教授　2008/08/01~2013/07/31
國立陽明大學附設醫院　牙科部副部主任　2008/08/01~2013/12/18
國立陽明大學附設醫院　 牙科部主治醫師　2008/01/01~2008/07/31　
台北榮民總醫院口腔醫學部特約醫師2005/01/01~
衛生署宜蘭醫院牙科主治醫師2004/09/02~2007/12/31
台北榮民總醫院牙科部口腔顎面外科住院醫師2002/06/01~2004/09/01
台北榮民總醫院牙科部口腔顎面外科進修住院醫師1998/10/01~2002/05/31
現職：
國立陽明交通大學牙醫學系副教授
國立陽明交通大學附設醫院牙科部主任
專長：口腔顎面外科、口腔癌分子生物學、口腔癌手術治療
聯絡電話：03-9325192-11630(醫院）02-28267029(學校）
電子郵件：hftu@nycu.edu.tw 

研究方向

“口腔癌致病機轉” “口腔癌治療“

研究計畫（5年內）

年度計畫名稱計畫內擔任之工作執行期間經費提供單位
2020建立類器官模型探討檳榔口腔癌化重要基因事件(109-2314-B-010-012-MY2)主持人2020/08/01~2022/07/31科技部
2019篩選及驗證口腔癌前病變惡化的關鍵突變(108-2314-B-010-014-)主持人2019/08/01~2020/07/3科技部
2018探討 MIR31HG 相關環狀 RNA 及長鍊非編碼 RNA 所扮演之口腔癌化角色(107-2314-B-010-031-)主持人2018/08/01~2019/07/31科技部
2018探討MIR31HG相關環狀RNA及長鍊非編碼RNA所扮演之口腔癌化角色　主持人2018/08/01~2019/07/31科技部
2017探討長?非編碼核糖核酸MIR31HG於口腔癌中之角色　主持人2017/01/01~2017/12/31嚴慶齡醫學研究中心
2014偵測高風險口腔癌前期病變基因組突變情形　主持人2014/03/01~2014/12/31國立陽明交通大學附設醫院
2013利用非侵襲性診斷以偵測口腔癌高風險族群（2/2）　主持人2013/08/01~2014/12/31國科會
2013薑黃素在口腔癌細胞株中對致癌性微型核醣核酸(miR-31)表現之調控　主持人2013/03/01~2013/12/31陽明交通大學附設醫院
2012EGFRvIII在頭頸癌細胞株抗藥性所扮演之角色　主持人2012/01/01~2012/12/31陽明交通大學附設醫院
2012利用非侵襲性診斷以偵測口腔癌高風險族群（1/2）　主持人2012/08/01~2013/07/31國科會
2011探討口腔癌組織中神經周圍侵犯之意義　主持人2011/08/01~2012/12/31嚴慶齡醫學研究中心
2011miR-31* 過客股微型RNA 及 RhoA 在口腔癌組織之拮抗表現於口腔癌侵襲及轉移之角色　主持人2011/01/01~2011/12/31附設醫院
2010微RNA miR-31及p53調控基因p53RPF與口腔癌放射抗性之角色研究(2/2)　主持人2010/08/01~2011/07/31國科會
2010微RNA miR-31及p53調控基因p53RPF與口腔癌放射抗性之角色研究(2/2)　主持人2010/08/01~2011/07/31國科會
2010微型RNA-149多型性與口腔麟狀細胞癌之關係　主持人2010/01/01~2010/12/31陽明交通大學附設醫院
2009探討血漿中腫瘤壞死因子第三號誘餌受體濃度與口腔癌病患預後之關係　主持人2009/01/01~2010/12/31陽明交通大學附設醫院
2009微RNA miR-31及p53調控基因p53RPF與口腔癌放射抗性之角色研究(1/2)　主持人2009/08/01~2010/07/31國科會
2008發展以血漿中微型RNA含量做為口腔癌生物標記之研究　主持人2008/10/20~2009/12/30陽明交通大學附設醫院

期刊論文(* 通訊作者)

  1. Chen, C. H., Huang, Y. C., Lee, Y. H., Tan, Z. L., Tsai, C. J., Chuang, Y. C., Tu,H. F., Liu, T. C., Hsu, F. T. (2020, Dec). Anticancer Efficacy and Mechanism of Amentoflavone for Sensitizing Oral Squamous Cell Carcinoma to Cisplatin. ANTICANCER RESEARCH, 40(12),6723-6732. MOST 108-2314-B-010-014. 本人為通訊作者.
  2. Li-Cho Hsu a, HSI-FENG TU b, Fei-Ting Hsu c, Po-Fu Yueh c, I-Tsang Chiang (2020, Jun). Beneficial effect of fluoxetine on anti-tumor progression on hepatocellular carcinoma and non-small cell lung cancer bearing animal model. BIOMEDICINE & PHARMACOTHERAPY, 126:110054.
  3. PEI-SHIH HUNG, FU-JIE CHUANG, CHIN-YAU CHEN, CHUNG-HSIEN CHOU, HSI-FENG TU and SU-SHUN LO (2020). miR-187* Enhances SiHaCervical Cancer Cell Oncogenicity Via Suppression of WWOX. ANTICANCER RESEARCH, 40(3),1427-1436.
  4. Huang LK, Tu HF, Jiang LD, Chen YY, Fu CY (2019, Nov). Evaluation of Concomitant Orbital Floor Fractures in Patients with Head Trauma Using Conventional Head CT Scan: A Retrospective Study at a Level II Trauma Center. Journal of Clinical Medicine, 8(11), 1852.
  5. Chen YF, Chang KW, Yang IT, Tu HF, Lin SC (2019, Aug). Establishment of syngeneic murine model for oral cancer therapy. Oral Oncology, 95:194-201.
  6. Tu HF, Chen YC Michael, Lai CY Joseph, Chen YL, Wong YW, Yang CC, CHen HY, Hsia SM, Shih YH, Shieh TM (2019, Aug). Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression. Head & Neck,41(8):2525-2537. 本人為第一作者.
  7. Peng SY, Tu HF, Yang CC, Wu CH, Liu CJ, Chang KW1, Lin SC. (2018, Dec). miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. International Journal of Cancer, 143(11):2892-2904. MOST 104-2314-B-010-046-MY3.
  8. Chou CH, Tu HF, Kao SY, Chiang CF, Liu CJ, Chang KW, Lin SC. (2018, Apr).Targeting of miR-31/96/182 to the Numb gene during head and neck oncogenesis. Head & Neck, 40(4):808-817. MOST 102-2628-B-010-011-MY3.
  9. Lim E, Kuo CC, Tu HF, Yang CC (2017, Oct). The prognosis outcome of oral squamous cell carcinoma using HIF-2α. Journal of the Chinese Medical Association, 80(10):651-656.
  10. Yu EH, Tu HF, Wu CH, Yang CC, Chang KW (2017, Jun). MicroRNA-21 promotes perineural invasion and impacts survival in patients with oral carcinoma.. Journal of the Chinese Medical Association, 80(6):383-388.
  11. Lu WC, Liu CJ, Tu HF, Chung YT, Yang CC, Kao SY, Chang KW, Lin SC. (2016, Aug). miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma. Oncotarget, Epub ahead of print.
  12. Yang CC, Tu HF, Wu CH, Chang HC, Chiang WF, Shih NC, Lee YS, Kao SY, Chang KW (2016, May). Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC. Oral Oncology, 56:54-61.
  13. Hung KF, Liu CJ, Chiu PC, Lin JS, Chang KW, Shih WY, Kao SY, Tu HF (2016, Feb). MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder. Oral Oncology, 53:42-7. MOST 101-2314-B-010-051-MY2. 本人為通訊作者.
  14. Kao YY, Tu HF, Kao SY, Chang KW, Lin SC (2015, Nov). The increase of oncogenic miRNA expression in tongue carcinogenesis of a mouse model. Oral Oncology, 51(12):1103-12.
  15. Tu HF, Chang KW, Cheng HW, Liu CJ (2015, Nov). Upregulation of miR-372 and -373 associates with lymph node metastasis and poor prognosis of oral carcinomas. The Laryngoscope, 125(11):E365-70. 本人為第一作者.
  16. Lu WC, Kao SY, Yang CC, Tu HF, Wu CH, Chang KW, Lin SC (2014, Sep).EGF up-regulates miR-31 through the C/EBPβ signal cascade in oral carcinoma. PLoS One, 9(9):e108049.
  17. Hung PS, Tu HF, Kao SY, Yang CC, Liu CJ, Huang TY, Chang KW, Lin SC (2014). miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes. Carcinogenesis, 35(5):1162-71. 本人為第一作者.
  18. Chang KW, Kao SY, Wu YH, Tsai MM, Tu HF, Liu CJ, Lui MT, Lin SC (2013,Jul). Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA. Oral Oncology, 49(1):27-33.
  19. Tu HF, Lin SC, Chang KW (2013, Apr). MicroRNA aberrances in head and neck cancer: pathogenetic and clinical significance. Current Opinion in Otolaryngology & Head and Neck Surgery, 21(2):104-11. 本人為第一作者.
  20. Liu, C. J. Tsai, M. M. Tu, H. F. Lui, M. T. Cheng, H. W. Lin, S. C.. miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas. ANNALS OF SURGICAL ONCOLOGY 2013; Suppl 3:S406-14 (SCI). (Impact factor: 4.041;Rank: 8.38%)第三作者
  21. Lo SS, Hung PS, Chen JH, Tu HF, Fang WL, Chen CY, Chen WT, Gong NR, Wu CW. Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma. ONCOGENE 2012; 31(2):226-37 (SCI). (Impact factor: 7.519;Rank: 6.89%)第四或以後作者
  22. Tu HF, Liu CJ, Chang CL, Wang PW, Kao SY, Yang CC, Yu EH, Lin SC, Chang KW. The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. PLoS One 2012; 7(12):e51606 (SCI). (Impact factor: 2.806;Rank: 22.66%)第一或通訊作者
  23. Wang, M. C. Hung, P. S. Tu, H. F. Shih, W. Y. Li, W. C. Chang, K. W.. Lipopolysaccharide induces the migration of human dental pulp cells by up-regulating miR-146a. JOURNAL OF ENDODONTICS 2012; 38(12):1598-603 (SCI). (Impact factor: 2.807;Rank: 16.11%)第三作者
  24. Tu HF, Liu CJ, Liu SY, Chen YP, Yu EH, Lin SC, Chang KW. Serum decoy receptor 3 level: A predictive marker for nodal metastasis and survival among oral cavity cancer patients. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 2011; 33(3):396-402 (SCI). (Impact factor: 3.376;Rank: 1.19%)第一或通訊作者
  25. Tu HF, Chang KW, Chiang WF, Liu CJ, Yu EH, Liu ST, Lin SC. The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas. ORAL ONCOLOGY 2011; 47(3):211-216 (SCI). (Impact factor: 4.794;Rank: 0.56%)第一或通訊作者
  26. Chiu YW, Tu HF, Wang IK, Wu CH, Chang KW, Liu TY, Kao SY.. The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis. ORAL ONCOLOGY 2010; 46(4):302-6 (SCI). (Impact factor: 4.794;Rank: 0.56%)第二作者
  27. Shieh TM, Chang KW, Tu HF, Shih YH, Ko SY, Chen YC, Liu CJ. Association between the polymorphisms in exon 12 of hypoxia-inducible factor-1α and the clinicopathological features of oral squamous cell carcinoma. ORAL ONCOLOGY 2010; 46(9):e47-e53 (SCI). (Impact factor: 4.794;Rank: 0.56%)第三作者
  28. Kao SY, Chen YP, Tu HF, Liu CJ, Yu AH, Wu CH, Chang KW. Nuclear STK15 expression is associated with aggressive behaviour of oral carcinoma cells in vivo and in vitro. JOURNAL OF PATHOLOGY 2010; 222(1):99-109 (SCI). (Impact factor: 6.894;Rank: 3.16%)第三作者
  29. Liu, C. J., Kao, S. Y., Tu, H. F., Tsai, M. M., Chang, K. W., Lin, S. C.. Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. ORAL DISEASES 2010; 16(4):360-364 (SCI). (Impact factor: 2.011;Rank: 29.44%)第三作者
  30. Shieh TM, Tu HF, Ku TH, Chang SS, Chang KW, Liu CJ. Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers. JOURNAL OF ORAL PATHOLOGY & MEDICINE 2009; 38(1):109-113 (SCI). (Impact factor: 2.043;Rank: 28.33%)第二作者
  31. Wu CH, Tu HF, Gong NR, Chen YW, Liu CJ, Kao SY. The Val allele of HER-2 codon 655 predicts the progression of oral squamous cell carcinoma. ORAL ONCOLOGY 2009; 45(7):579-583 (SCI). (Impact factor: 4.794;Rank: 0.56%)第二作者
  32. Liu HS, Lu HH, Lui MT, Yu EH, Shen W, Chen YP, Chang KW, Tu HF. Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers. ORAL ONCOLOGY 2009; 45(12):1032-6 (SCI). (Impact factor: 4.794;Rank: 0.56%)第一或通訊作者
  33. Hung PS, Kao SY, Liu CJ, Tu HF, Wu CH, Lin SC. Insulin-like growth factor binding protein-5 enhances the migration and differentiation of gingival epithelial cells. JOURNAL OF PERIODONTAL RESEARCH 2008; 43(6):673-80 (SCI). (Impact factor: 2.662;Rank: 18.33%)第四或以後作者
  34. Tu HF, Chen HW, Kao SY, Lin SC, Liu CJ, Chang KW. MDM2 SNP 309 and p53 codon 72 polymorphisms are associated with the outcome of oral carcinoma patients receiving postoperative irradiation. RADIOTHERAPY AND ONCOLOGY 2008; 87(2):243-52 (SCI). (Impact factor: 4.328;Rank: 10.63%)第一或通訊作者
  35. Chen, Y. W. Tu, H. F. Wu, T. H. Lo, W. L. Chang, C. S. Chang, K. W. Kao, S. Y.. Sarcomas and sarcomatoid tumor after radiotherapy of oral squamous cell carcinoma: analysis of 4 cases. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS 2008; 105(1):65-71 (SCI). (Impact factor: 1.581;Rank: 47.27%)第二作者
  36. Tu HF, Wu CH, Kao SY, Liu CJ, Liu TY, Lui MT. Functional -1562 C-to-T polymorphism in matrix metalloproteinase-9 (MMP-9) promoter is associated with the risk for oral squamous cell carcinoma in younger male areca users. JOURNAL OF ORAL PATHOLOGY & MEDICINE 2007; 9((7):409-14 (SCI). (Impact factor: 2.043;Rank: 28.33%)第一或通訊作者
  37. Kao SY, Fong JH, Chou SJ, Wu JH, Tu HF, Yeung TC. Segmental osteotomy to reposition multiple osseointegrated dental implants in the anterior maxilla in a trauma patient. DENTAL TRAUMATOLOGY 2007; 23(1):56-9 (SSCI). (Impact factor: 1.413;Rank: 52.78%)第四或以後作者
  38. Tu, H. F. Liu, C. J. Chang, C. S. Lui, M. T. Kao, S. Y. Chang, C. P. Liu, T. Y.. The functional (-1171 5A–>6A) polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users. JOURNAL OF ORAL PATHOLOGY & MEDICINE 2006; 35(2):99-103 (SCI). (Impact factor: 2.043;Rank: 28.33%)第一或通訊作者
  39. Kao SY, Tu HF, Chang KW, Chang CS, Yang AH, Li WY. Epithelioid sarcoma metastasis to the gingivae: a case report. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 2004; 33(2):205-8 (SCI). (Impact factor: 1.918;Rank: 32.78%)第二作者
  40. Kao, S. Y. Tu, H. F. Chang, K. W. Chang, C. S. Yang, C. C. Lin, S. C.. The retinoic acid receptor-beta (RAR-beta) mRNA expression in the oral squamous cell carcinoma associated with betel quid use. JOURNAL OF ORAL PATHOLOGY & MEDICINE 2002; 31(4):220-6 (SCI). (Impact factor: 2.043;Rank: 28.33%)第二作者
  41. Kao SY, Tu, H. F. Chang RC, Yang AH, Chang KW, Lee CH. Primary ectopic thyroid papillary carcinoma in the floor of the mouth and tongue: a case report. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 2002; 40(3):213-5 (SCI). (Impact factor: 1.218;Rank: 67.22%)第二作者

研討會發表

  1. 24th International Conference on Oral & Maxillofacial Surgery, ICOMS 2019, 5/21-5/24, Rio, Brazil “Areca related oral carcinogenesis in Taiwan” (invited speech)
  2. AACR 2018 4/14-4/18, USA Tumor suppressor Numb represses monocarboxylate transporters to reduce the glycolysis in oral carcinoma (poster)
  3. EACMFS 2016, London, UK “SOMATIC MUTATION PROFILE OF ARECA-RELATED ORAL SQUAMOUS CELL CARCINOMA BY EXOME SEQUENCING” (poster)                  
  4. HSI-FENG TU, Chung-Ji Liu, Kuo-Wei Chang, DETECTION OF MIR-21 AND MIR-31 AS A DIAGNOSTIC TOOL FOR HIGH-RISK ORAL POTENTIALLY MALIGNANT DISORDERS,5th World Congress of the International Academy of Oral Oncology, IAOO 2015,聖保羅,2015
  5. HSI-FENG TU, Cheng-Chieh Yang, Areca up-regulates COX-2 to modulate HB-EGF expression and the consequent chemo-resistance in HNSCC (poster 401),XXII Congress of the European Association of Cranio-Maxillo-Facial Surgery,Prague,,2014
  6. Wen-Cheng Lu, Kuo-Wei Chang, Shu-Chun Lin, HSI-FENG TU, MicroRNA-31 is up-regulated by EGF through C/EBPβ signaling,The 105th Annual Meeting of the American Association for Cancer,聖地牙哥,2014
  7. HSI-FENG TU, Pei-Shi Hung, Shou-Yen Kao, Ting-Hui Chiua, Cheng-Chieh Yang, Chung-Ji Liu, Shu-Chun Lin, Kuo-Wei Chang, MicroRNA-31 is up-regulated in oral premalignant epithelium and is contributive to the immortalization of normal oral keratinocyte,American Association of Cancer Research Annual Meeting 2013, AACR 2013,華聖頓,2013
  8. HSI-FENG TU, Chung-Ji Liu, Che-Lun Chang, Pei-Wen Wang, Shou-Yen Kao, Cheng-Chieh Yang, En-Hao Yu, Shu-Chun Lin, Kuo-Wei Chang, The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of HNSCC Patients,4th World Congress of the International Academy of Oral Oncology, IAOO,羅德斯島,2013
  9. HSI-FENG TU, Chung-Ji Liu, Shou-Yen Kao, Yi-Hsuan Wua, Shu-Chun Lin, Kuo-Wei Chang, Passenger strand mcroiRNA miR-31* regulates the phenotypes of oral cancer cells,10th Asian Congress on Oral and Maxillofacial Surgery, ACOMS,巴里島,2012
  10. 涂曦丰、蔣維凡、于恩浩、張國威, The frequent amplification and co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas,2011口腔病理新知研討會,台灣大學附設醫院,2011
  11. 涂曦丰、劉崇基、張國威, MDM2及 p53基因多型性影響接受放射線治療口腔癌病患之預後,中華民國口腔顎面外科學會九十七年度第二十次學術研討會,中國醫藥大學,2008
  12. HSI-FENG TU, Shu-Chun Lin, Hong-Wen Chen, Shou-Yen Kao, Chung-Ji Liu, MDM2 SNP 309 G/G and p53 codon 72 Arg/Arg genotypes predict poor survival and control of oral carcinoma after postoperative irradiation,The Third Meeting of Asian Society of Oral and Maxillofacial Pathology,台北福華飯店,2007
  13. 涂曦丰、張舜閩、林姝君、張國威, 口腔鱗狀上皮細胞癌細胞核內類胰島素生長因子結合蛋白-5之表現與功能,中華民國口腔顎面外科學會九十五年度第十八次學術研討會,台南奇美醫院,2006
  14. HSI-FENG TU, Chung-Ji Liu, Shou-Yen Kao,Kuo-Wei Chang, The role of MDM2 polymorphism in areca-related oral squamous cell carcinoma,The 7th Asian Congress on Oral and Maxillofacial Surgery,Hong Kong,2006
  15. 涂曦丰、劉崇基、高壽延, 基質裂解酵素（MMP3）基因上之具功能性單一核甘酸多型性與口腔癌感受性相關,中華民國口腔顎面外科學會九十四年度第十七次學術研討會,三軍總醫院,2005
  16. 涂曦丰、李永賢、高壽延, 口腔鱗狀細胞癌放射線治療後發生之肉瘤：二病例報告,中華民國口腔顎面外科學會九十三年度第十六次學術研討會,彰化基督教醫院,2004
  17. 涂曦丰、高壽延、劉宗榮, 髓過氧化物酵素基因多型性與口腔鱗狀細胞癌之關係之研究,中華民國口腔顎面外科學會九十二年度第十五次學術研討會,三軍總醫院,2003
  18. 涂曦丰、張國威、高壽延, 發生於上顎齒齦處之周邊T細胞淋巴瘤-病例報告,中華民國口腔顎面外科學會九十一年度第十四次學術研討會,國立成功大學,2002
  19. 涂曦丰、張國威、高壽延, 維生素A酸核受器β在口腔頰黏膜鱗狀細胞癌組織與正常組織中之差異性表現之研究,中華民國口腔顎面外科學會八十九年度第十二次學術研討會,高雄醫學大學,2000

得獎紀錄

  1. 中華民國牙醫師公會全國聯合會特殊貢獻獎 銅質獎 (2020)
  2. 中華民國牙醫師公會全國聯合會教學優良教師 (2017)