李士元 終身特聘教授 (Lee, Shyh-Yuan)

經歷：

經歷：

現職：

國立陽明交通大學牙醫學系 特聘教授

台北榮民總醫院口腔醫學部兼任主治醫師

台北市立聯合醫院醫研部兼任研究員

專長：牙科材料學、牙科贗復學、牙科植體學、數位牙醫學

聯絡電話：(02) 2826-7235

傳真電話：(02) 2826-4053

電子郵件：sylee@nycu.edu.tw

研究方向

(1)紅外光同調斷層掃瞄系統利用紅外光以及同調斷層掃描技術(Optical Coherence Tomography, OCT)可以穿透部分牙組織，取得牙齦下牙表面的訊號，經由程式回歸真實位置後再組成三維數位模型，相較於目前市售口掃機，本系統可以在免排齦的情況下，取得製作贋復牙所需之完整磨牙外觀與邊界，結合三維列印系統，便可以發展出獨特的數位贋復製造流程。另外，此系統亦有牙病偵測之發展潛力，可以偵測牙齦下牙結石、二次蛀牙、牙齒微裂縫等不易從表面觀測之疾病。

(2)三維列印系統整合研究應用臨床牙醫，包含高分子列印的應用於臨時假牙、全口假牙、咬合板、手術導板；以及金屬列印應用於客製化人工牙根的開發，以解決牙床嚴重吸收而無法進行傳統植牙手術的患者進行全口重建。

研究計畫（5年內）

獲獎項目

2022  中華民國牙醫師公會全國聯合會教學優良教師

2021  台北榮民總醫院 最佳教學主治醫師獎

2010~2021 陽明大學學術卓越獎勵 (2016~特聘教授)

2021  教育部教學實踐研究計畫(108年)績優計畫

2020  初創企業國家新創獎 

2019  台北榮總60週年重大成就醫療技術創新獎第一名         

2019  臺北榮民總醫院 醫師創新改良獎第一名

2018  科技部未來科技展

2018  台灣創新技術博覽會「創新發明館」

2017  科技部工程司傑出展示獎

2016  衛福部食藥署 醫療器材創新研發貢獻獎

2016  台北國際發明金牌獎

2015  台北榮民總醫院 最佳教學主治醫師獎 

2015  國立陽明大學 教學傑出獎       

2014  中華民國牙醫師公會全國聯合會 金質獎       

2014   陽明大學傑出校友

專利

1. Jaw motion tracking system and operating method using the same (2020) 美國發明專利(公開號US2010751152B2) 發明人：鄭量元、許至瑜、李士元、林元敏
2. Three-Dimensional Printing Methods and Materials for Making Dental Products (2020) 美國發明專利(公開號US20180258290A1) 領證中，發明人：林元敏,陳翾,李士元,黃品儒
3. 光断层扫描数字印模取像系统及其使用方法(2020) 中國發明專利CN108135472 B，發明人：李士元、呂志偉、呂東原、賴昱臻
4. Optical Tomography Digital Impression Imaging System and Method for Use Thereof (2019)美國發明專利US10426346B2，發明人：李士元、呂志偉、呂東原、賴昱臻
5. 全口假牙之三維列印製造方法(2019) 中華民國I679102，發明人：江卓培、許煌展、李士元、林宗翰
6. 咬合運動追蹤系統與其使用方法(2019),中華民國 發明專利號I630904, 發明人：鄭量元、許至瑜、李士元、林元敏　
7. 用於三維列印之生物可分解的光聚合組合物(2019),中華民國 發明專利號I654246，發明人：林元敏、江卓培、 李士元、 林賢達
8. 三維列印用牙科材料及其製備方法與應用(2018)，中華民國 發明專利號I630244，發明人：林元敏、陳翾、李士元、黃品儒
9. 可光緊合的生物可分解聚合物及其製備方法(2018)，中華民國發明專利號I614280，發明人：林元敏、江卓培、李士元、黃品儒
10. 光斷層掃描數位印模取像系統及其使用方法(2017)，中華民國發明專利號 I592145，發明人：李士元、呂志偉、呂東原、賴昱臻
11. System and Method for Detecting Bone Defects (2017)， 美國發明專利號US 9788749，發明人: 潘敏俊、謝大誠、陳錦松、李士元
12. 具有多材料之三維列印方法(2016)，中華民國發明專利號I561369，發明人：江卓培，許煌展，李士元
13. 骨缺損檢測系統、裝置及方法(2016)，中華民國發明專利號I546060，發明人：潘敏俊、謝大誠、陳錦松、李士元
14. 一種牙結石成像方法(2015)，中華民國發明專利號I481392 ，發明人：李士元、孫家偉 、何怡青、謝曜聲、莊競程
15. 牙科植體不規則骨缺損檢測裝置及其方法(2012)，中華民國發明專利號I365736，發明人：潘敏俊、莊瀚伯、李士元
16. Apparatus and Method of Irregular Bone Defect Detection of Dental Implant. (2012)美國發明專利號 US 8,167,614，發明人：潘敏俊、莊瀚伯、李士元

期刊論文

1. Hsiao TY, Ho YC, Lee SY, Sun CW. Degree of polarization uniformity for dental calculus visualization. Journal of Biophotonics 2022; 15(6):e202200011 (SCI).
2. Siu WS, Shih YF, Lee SY, Hsu CY, Wei MJ, Wang TJ, Lin HC, Lin YL. Alterations in kinematics of temporomandibular joint associated with chronic neck pain. JOURNAL OF ORAL REHABILITATION 2022; 49(9):860-871 (SCI).
3. Jiang CP, Cheng YC, Lin HW, Chang YL, Pasang T, Lee SY. Optimization of FDM 3D printing parameters for high strength PEEK using the Taguchi method and experimental validation. Rapid Prototyping Journal 2022:28(7):1260–1271 (SCI).
4. Lin CS, Liu LK, Lee WJ, Peng LN, Lin CP, Lee SY, Chen LK,. Low masseter muscle mass is associated with frailty in community-dwelling older adults. Experimental Gerontology 2022; 163:163:111777 (SCI)
5. Tsai ST, HO IC, Tsai JL, Yang SF, Lai YL, Lee SY.. Evaluation of students’ self-assessment performance in preclinical endodontic training by means of rubrics and a 3D printed model. Journal of the Formosan Medical Association 2022; 121(11):2203-2210 (SCI).
6. Yen JY, Kang L, Chou IC, Lai YL, Lee SY. Risk assessment of interproximal contact loss between implant-supported fixed prostheses and adjacent teeth: A retrospective radiographic study. Journal of Prosthetic Dentistry 2022; 127(1):86-92 (SCI).
7. Wu SY, Wu CY, Chen MH, Huang HY, Chen YH, Tsao YP, Lai YL, Lee SY. Periodontal conditions in patients with Sjogren’s Syndrome: A meta-analysis. Journal of Dental Sciences 2021; 16(4):1222-1232 (SCI).
8. Su JJ, Lin CS, Chen H, Lee SY, Lin YM. Biofabrication of Cell-Laden Gelatin Methacryloyl Hydrogels with Incorporation of Silanized Hydroxyapatite by Visible Light Projection. Polymers 2021; 13(14):2354 (SCI).
9. Hsiao TY, Ho YC, Chen MR, Lee SY, Sun CW. Disease activation maps for subgingival dental calculus identification based on intelligent dental optical coherence tomography. Translational Biophotonics 2021:1-10 (OI).
10. Hwang JF, Chou IC, Lai YL, Lee SY. Forced Eruption in esthetic zone from the prosthetic point of view: A case report. Journal of Prosthodontics and Implantology 2021; :Accepted (OI).
11. Hwang JF, Chan KW, Chen HL, Lee SY. Restoration of flared incisor roots: a case report with 16 years of follow-up and review of literature. Journal of Prosthodontics and Implantology 2021; :Accepted (OI).
12. Jiang CP, Hentihu MFR, Lee SY, Lin R. Multiresin Additive Manufacturing Process for Printing a Complete Denture and an Analysis of Accuracy. 3D Printing and Additive Manufacturing. 2021: doi.org/10.1089/3dp.2021.0007 (SCI).
13. Lin CH, Lin YM, Lai YL, Lee SY. Mechanical properties, accuracy and cytotoxicity of the UV-cured 3D printing resins composed of BisEMA, UDMA and/or TEGDMA. Journal of Prosthetic Dentistry 2020;123(2): 349-354 (SCI).
14. Chen S, Lee SY, Lin YM. Synthesis and Formulation of PCL-Based Urethane Acrylates for DLP 3D Printers. Polymers 2020;12(7):1500 (SCI)
15. Lin YM, Chen H Lin CH, Huang PJ, & Lee SY. Development of Polycaprolactone Hydroxyapatite Composite resin for 405nm Digital Light Projection 3D printing. Rapid Prototyping Journal 2020:10.1108/RPJ-06-2019-0166 (SCI).
16. Hsu HJ, Lee SY, Jiang CP, Lin R. A comparison of the marginal fit and mechanical properties of a zirconia dental crown using CAM and 3DSP. Rapid Prototyping Journal 2019;25(7):1187-1197 (SCI).
17. Lai, YC, Lin, JY, Yao, CY, Lyu, DY, Lee, SY, Chen, KW, Chen, IY. Interactive OCT-Based Tooth Scan and Reconstruction. SENSORS; 2019; 19(19):4234 (SCI)
18. Lai, YC; Chiu, CH, Cai, ZQ, Lin, JY, Yao, CY, Lyu, DY, Lee, SY, Chen, KW, Chen, IY. OCT-Based Periodontal Inspection Framework. SENSORS; 2019; 19(22):5496 (SCI)
19. Hsiao TY, Lee SY, Sun CW. Optical polarimetric detection for dental hard tissue diseases characterization. SENSORS 2019; 19(22): 4971 (SCI)
20. Lin CH, Su JM, Lee SY, Lin YM. Stiffness Modification of Photopolymerizable Gelatin-Methacrylate Hydrogels Influences Endothelial Differentiation of Human Mesenchymal Stem Cells. Journal of Tissue Engineering and Regenerative Medicine 2018: DOI:10.1002/term.2745 (SCI).
21. Lee PH, Yew T L, Lai YL, Lee SY and Chen HL*. Parathyroid hormone gene-activated matrix with DFDBA/collagen composite matrix enhances bone regeneration in rat calvarial bone defects. Journal of the Chinese Medical Association: JCMA 2018; 81(ahead):699-707 (SCI).
22. Chang WT, Hsu HJ, Jiang CP, Lee SY, Lin YM. Effects of titanium dioxide and tartrazine lake on Z-axis resolution and physical properties of resins printed by visible-light 3D printers. Rapid Prototyping Journal 2018; 24(1):160-165 (SCI).
23. Tzeng JJ, Hsiao YT, Wu YC, Chen H, Lee SY, Lin YM. Synthesis, Characterization, and Visible Light Curing Capacity of Polycaprolactone Acrylate. Biomed Research International 2018; 2018: Article ID 8719624, 8 pages (SCI).
24. Lee SY, Wu SC, Chen S, Tsai LL, Tzeng JJ, Lin CH, Lin YM. Synthesis and characterization of polycaprolactone-based polyurethanes for the fabrication of elastic guided bone regeneration membrane. Biomed Research International 2018; 2018: Article ID 3240571, 13 pages (SCI).
25. Lee CY, Chung CC, Chen GJ, Huang CC, Lee SY, Lin YH. Automated Segmentation of Dental Calculus in Optical Coherence Tomography Images. SENSORS AND MATERIALS 2018; 30(11):2517-2529 (SCI).
26. Hsu FJ, Lee SY, Jiang CP. Technical Development of Multi-Resin Three-Dimensional Printer Using Bottom-Up Method. International Journal of Automation and Smart Technology 2018; 8(4):173-178 (OI).
27. Wu SY, Wu CY, Chen MH, Tsao YP, Lee SY. Oral care for Sjogren’s syndrome patient. Clinical Medicine (in Chinese) 2018(7): 421-424 (OI).
28. Hsu HJ, Lee SY, Chang SK, Jiang CP. Surface Modification of High Density Ceramic Powder for Increasing Suspension Capacity in Three-Dimensional Printing Application. Material Science Forum 2018; 936:159-163 (EI).
29. Lee PH, Chen MY, Lai YL, Lee SY and Chen HL. Human Beta-Defensin-2 and -3 Mitigate the Negative Effects of Bacterial Contamination on Bone Healing in Rat Calvarial Defect. Tissue Engineering 2018; 24(7-8): doi: 10.1089/ten.TEA.2017.0219 (SCI).
30. Hsu HJ, Lee SY, Chang SL*, Lo CH, Lin YM. Shrinkage prediction using finite element analysis and experimental validation using three-dimension slurry printing system. International Journal of Advanced Manufacturing Technology 2017; 91(1-4):1289–1296 (SCI).
31. Lin CH, Chang MC, Hung SC, Lee SY, Lin YM. Bioactive surface modification of polycaprolactone using MG63-conditioned medium can induce osteogenic differentiation of mesenchymal stem cells. Journal of Materials Science 2017; 52(7):3967–3978 (SCI).
32. Chen HH, Lin YC, Lee SY, Chang LY, Chen BJ, Lai YL. Influence of sinus floor configuration on the grafted bone remodeling following osteotome sinus floor elevation. Journal of Periodontology 2017; 88(1):10-16 (SCI).
33. Lin CH, Lee SY, Lin YM. Plasma Treatment in Conjunction with EGM-2 Medium Increases Endothelial and Osteogenic Marker Expressions of Bone Marrow Mesenchymal Stem Cells. Journal of Materials Science 2016; 51(19):9145-54 (SCI).
34. Chung HK, Lee SY. Analysis of Dental Color Matching Devices and Systems. Journal of Family Dentistry 2016; 11(2):5-11 (OI).
35. Lin CH, Lin KF, Mar K, Lee SY, Lin YM. Antioxidant N-acetylcysteine and glutathione increase the viability and proliferation of MG63 cells encapsulated in the gelatin-methacrylate/VA-086/blue light hydrogel system. Tissue Engineering 2016; 22(8):792-800 (SCI).
36. Cheng YC, Lin DH, Jiang CP, Lee SY. Design improvement and dynamic finite element analysis of novel ITI dental implant under dynamic chewing Bio-Medical Materials and Engineering 2015; 26(S):555-561 (SCI).
37. Chiou YT, Ho YC, Lee SY. Introduction of Digital Intraoral Scanner. Journal of Family Dentistry 2015; 10(3):4-13 (OI).
38. Chiu YW, Lee SY, Lin YC, Lai YL. Significance of the width of keratinized mucosa on peri-implant health. Journal of the Chinese Medical Association 2015;78:(7);389-394 (SCI).
39. Lin YC, Lee YY, Ho YC, Shieh YC, Lai YL, Lee SY. Treatment of Large Apical Lesions with Mucosal Fenestration: A Clinical Study with Long-term Journal of Endodontics 2015; 41(4):563-567 (SCI).
40. Sun CW, Ho YC, Lee SY. Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography. Journal of Sensors 2015; http://dx.doi.org/10.1155/2015/984627.(SCI).
41. Lee SY, Jiang CP. Development of a three-dimensional slurry printing system using dynamic mask projection for fabricating zirconia dental implants. Materials and Manufacturing Processes 2015; 575:214-218 (SCI).
42. Shih YH, Lin DJ, Chang KW, Hsia SM, Ko SY, Lee SY, Hsue SS, Wang TH, Chen YL, Shieh TM. Evaluation PhysicalCharacteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol in Vitro. PLOS ONE 2014;9(6): e94941 (SCI).
43. Chou IC, Lee SY, Jiang JP. Effects of implant neck design on primary stability and overload ina type IV mandibular bone. International Journal for Numerical Methods in Biomedical Engineering 2014;30(11):1223-1237 (SCI).
44. Hsu HJ, Lee SY, Jiang CP. Development of maskless-curing slurry stereolithography for fabricatinghigh strength ceramic parts. Advanced Materials Research 2014; 575:214-218 (EI).
45. Jiang CP, Hsu HJ, Lee SY. Development of Mask-less Projection Slurry Stereolithography for the Fabricationof Zirconia Dental Coping. International Journal of Precision Engineering and Manufacturing 2014;15(11):2413-2419 (SCI).
46. Chou IC, Lee SY, Wu MC, Sun CW, Jiang CP. Finite element modelling of implant designs andcortical bone thickness on stress distribution in maxillary type IV bone. Computer Methods in Biomechanics and Biomedical Engineering 2014;17(5):516-526 (SCI).
47. Sun CW, Lee SY, Lin KF. Optical scanningprobe for bioimaging of optical coherence tomography. Journal of Medical and Biological Engineering 2014;34(1):95-100 (SCI).
48. Lin GH, Chang LY, Lin WC, Lee SY, Lai YL. Interdisciplinary approach for treating a largethrough-and-through periapical defect using guided tissue regeneration: A case report with seven-year follow-up. International Journal of Periodontics & Restorative Dentistry 2014;34(1): e1-e8 (SCI).
49. Huang YM, Chou IC, Jiang CP, Wu YS, Lee SY. Finite Element Analysis of Dental Implant Neck Effects on Primary Stability and Osseointegration in a Type IV Bone Mandible. Bio-Medical Materials and Engineering 2014;24(1):1407-1415 (SCI).
50. Lin CS, Hsieh JC, Yeh TC, Lee SY, Niddam DM. Functional dissociation within insular cortex: the effect of pre-stimulus anxiety on pain. Brain Research 2013;1493:40-47 (SCI).
51. Zhuang HB, Tu WS, Pan MC, Wu JW, Chen CS, Lee SY and Yang YC. Noncontact vibro-acoustic detection technique for dental osseointegration examination. Journal of Medical and Biological Engineering 2013;33(1):35-44 (SCI).
52. Pan MC, Zhuang HB, Chen CS, Wu JW, Lee SY. A noncontact resonance frequency detection technique for the assessment of the interfacial bone defect around a dental implant. Medical Engineering & Physics 2013;doi:10.1016/j.medengphy.2013.05.006 (SCI).
53. Hsieh YS, Lee SY, Ho YC, Chuang CC, Tsai JC, Lin KF, Su CW. Dental Optical Coherence Tomography. Sensors 2013; 13(7):8928-8949; doi:10.3390/s130708928 (SCI).
54. Lee WJ, Lai YL, Lee SY. Sleep Bruxism and Associated Physiological Changes. J Dent Sci 2013;31(1):16-26 (OI)
55. Sun CW, Hsieh YS, Ho YC, Jiang CP, Chuang CC, Lee SY.. Characterization of tooth structure and the dentin-enamel zone based on the Stokes-Mueller calculation. Journal of Biomedical Optics 2012;17(11):116026 (1-6) (SCI).
56. Wei YJ, Lin YJ, Kaung SS, Yang SF, Lee SY, Lai YL. Esthetic periodontal surgery for impacted dilacerated maxillary central incisors. American Journal of Orthodontics and Dentofacial Orthopedics 2012;142(4):546-51 (SCI).

研究成果圖

免排齦口掃機  附研究方面之圖一張（電子檔）

OCT口內掃描影像沒有輻射的風險，藉由紅外線能穿透一定深度的組織取得立體影像，可用於檢測初期齲齒、臨接面齲齒、樹脂下齲齒、齒裂症、牙齦下結石、口腔黏膜活體切片影像；同時藉由光學修正可以精確取得牙齦下修磨邊界，完成免排齦3D建模。本研究以OCT影像搭配3D齒雕試做的臨時牙冠，可獲得密合度精準的邊界。