{"id":2481,"date":"2021-11-30T03:34:44","date_gmt":"2021-11-30T03:34:44","guid":{"rendered":"https:\/\/dod.nycu.edu.tw\/?page_id=2481"},"modified":"2023-07-18T09:40:25","modified_gmt":"2023-07-18T09:40:25","slug":"%e5%bc%b5%e5%a9%b7%e8%8f%a1-%e5%8a%a9%e7%90%86%e6%95%99%e6%8e%88-chang-ting-han","status":"publish","type":"page","link":"https:\/\/dod.nycu.edu.tw\/?page_id=2481","title":{"rendered":"\u5f35\u5a77\u83e1 \u52a9\u7406\u6559\u6388 (Chang, Ting-Han)"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

\u5b78 \u6b77<\/strong>\uff1a<\/p>\n\n\n\n

\u7562\u696d\u5b78\u6821<\/td>\u570b\u5225<\/td>\u4e3b\u4fee\u7cfb\u5225<\/td>\u5b78\u4f4d<\/td>\u7562\u696d\u5e74\u5ea6<\/td><\/tr>
\u8cd3\u5915\u6cd5\u5c3c\u4e9e\u5927\u5b78<\/td>\u7f8e\u570b<\/td>\u7259\u91ab\u79d1\u5b78<\/td>\u535a\u58eb<\/td>2020<\/td><\/tr>
\u4e2d\u5c71\u91ab\u5b78\u5927\u5b78<\/td>\u53f0\u7063<\/td>\u7259\u91ab\u5b78\u7cfb<\/td>\u5b78\u58eb<\/td>2008<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u5b78\u8853\u7d93\u6b77\uff1a<\/strong><\/p>\n\n\n\n

\u5e74\u5ea6<\/td>\u670d\u52d9\u55ae\u4f4d<\/td>\u670d\u52d9\u90e8\u9580<\/td>\u8077\u7a31<\/td><\/tr>
2021\/02-<\/td>\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78<\/td>\u7259\u91ab\u5b78\u7cfb<\/td>\u52a9\u7406\u6559\u6388<\/td><\/tr>
2021\/02-<\/td>\u632f\u8208\u91ab\u7642\u8ca1\u5718\u6cd5\u4eba\u632f\u8208\u91ab\u9662<\/td>\u7259\u79d1\u90e8<\/td>\u7279\u7d04\u4e3b\u6cbb\u91ab\u5e2b<\/td><\/tr>
2014-2015<\/td>\u57fa\u7763\u5fa9\u81e8\u5b89\u606f\u65e5\u6703\u91ab\u7642\u8ca1\u5718\u6cd5\u4eba\u81fa\u5b89\u91ab\u9662<\/td>\u7259\u79d1\u90e8<\/td>\u4e3b\u6cbb\u91ab\u5e2b<\/td><\/tr>
2014-<\/td>\u4e2d\u83ef\u6c11\u570b\u53e3\u8154\u984e\u9762\u5916\u79d1\u5b78\u6703<\/td> <\/td>\u53e3\u8154\u984e\u9762\u5916\u79d1\u5c08\u79d1\u91ab\u5e2b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u3010\u69ae\u8b7d\u6210\u5c31\u3011<\/p>\n\n\n\n

\u5e74\u5ea6<\/td>\u55ae\u4f4d<\/td>\u734e\u9805<\/td><\/tr>
2017<\/td>\u7f8e\u570b\u8cd3\u5915\u6cd5\u5c3c\u4e9e\u5927\u5b78\u7259\u91ab\u5b78\u9662<\/td>\u9752\u5e74\u7814\u7a76\u5b78\u8005\u7d44\u4e4b\u5b78\u8853\u7af6\u8cfd_2018\u7f8e\u570b\u7259\u91ab\u5b78\u7814\u7a76\u8a0e\u8ad6\u6703\u7814\u7fd2\u734e<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u73fe \u8077\uff1a<\/strong><\/p>\n\n\n\n

\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u7259\u91ab\u5b78\u7cfb \u5c08\u4efb\u52a9\u7406\u6559\u6388<\/p>\n\n\n\n

\u632f\u8208\u91ab\u7642\u8ca1\u5718\u6cd5\u4eba\u632f\u8208\u91ab\u9662 \u7259\u79d1\u90e8 \u7279\u7d04\u4e3b\u6cbb\u91ab\u5e2b<\/p>\n\n\n\n

\u5c08 \u9577<\/strong>\uff1a<\/strong><\/strong><\/p>\n\n\n\n

\u53e3\u8154\u984e\u9762\u5916\u79d1\u624b\u8853\u3001\u816b\u7624\u5e79\u7d30\u80de\u751f\u7269\u5b78\u3001\u53e3\u8154\u5e79\u7d30\u80de\u65bc\u7d44\u7e54\u5de5\u7a0b\u61c9\u7528\u3001\u4e09\u7dad\u7acb\u9ad4\u985e\u5668\u5b98\u6a21\u578b\u5efa\u7acb<\/p>\n\n\n\n

\u806f\u7d61\u96fb\u8a71\uff1a(02) 2826-7118<\/p>\n\n\n\n

\u50b3\u771f\u96fb\u8a71\uff1a(02) 2826-4053<\/p>\n\n\n\n

\u96fb\u5b50\u90f5\u4ef6: cth0616@nycu.edu.tw<\/a><\/p>\n\n\n\n

\u5be6\u9a57\u5ba4\u7814\u7a76\u65b9\u5411<\/strong><\/p>\n\n\n\n

\u9020\u91c9\u7d30\u80de\u7624\u662f\u984e\u9aa8\u5e38\u898b\u7684\u826f\u6027\u9f52\u6e90\u6027\u4e0a\u76ae\u816b\u7624\uff0c\u5177\u6709\u5c40\u90e8\u4fb5\u72af\u6027\u548c\u9ad8\u5fa9\u767c\u7387\uff0c\u81f3\u4eca\uff0c\u6211\u5011\u4ecd\u4e0d\u6e05\u695a\u5176\u767c\u75c5\u548c\u5fa9\u767c\u6a5f\u5236\uff0c\u70ba\u964d\u4f4e\u816b\u7624\u5fa9\u767c\uff0c\u63a1\u4ee5\u5ee3\u6cdb\u6027\u984e\u9aa8\u5207\u9664\uff0c\u4f46\u5982\u6b64\u4ea6\u964d\u4f4e\u75c5\u4eba\u7684\u53e3\u8154\u529f\u80fd\u548c\u751f\u6d3b\u54c1\u8cea\u3002\u6211\u5011\u4e4b\u524d\u767c\u73fe\u9020\u91c9\u7d30\u80de\u7624\u4e2d\u7684LGR5\u985e\u5e79\u7d30\u80de\u4ee3\u8868\u4e00\u7fa4\u4e0a\u76ae\u7d30\u80de\u9593\u8cea\u8f49\u5316(epithelial-mesenchymal transition, EMT)\u4e4b\u4e2d\u9593\u7d30\u80de\uff0c\u53ef\u4ee5\u62b5\u6297BRAFV600E\u6291\u5236\u5291\u800c\u518d\u751f\u816b\u7624\u985e\u5668\u5b98\uff0c\u4e14\u816b\u7624\u9593\u8cea\u7d30\u80de\u53ef\u4ee5\u4fc3\u9032\u4e0a\u76ae\u5e79\u7d30\u80de\u548cEMT\u7684\u7279\u6027\u3002\u80da\u80ce\u5e79\u7d30\u80de\u85c9\u7531\u4e8c\u50f9\u7d44\u7e54\u86cb\u767d\u4fee\u98fe\uff0c\u5feb\u901f\u56e0\u61c9\u74b0\u5883\u6539\u8b8a\u800c\u8868\u9054\u6216\u95dc\u9589\u57fa\u56e0\uff0c\u90e8\u5206\u764c\u75c7\u4e5f\u767c\u73fe\u985e\u4f3c\u7684\u8abf\u63a7\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c0d\u65bc\u816b\u7624\u5fae\u74b0\u5883\u662f\u5426\u900f\u904e\u8868\u89c0\u907a\u50b3\u5b78\u8abf\u63a7LGR5\u9020\u91c9\u7d30\u80de\u7624\u5e79\u7d30\u80de\uff0c\u9032\u800c\u62b5\u6297\u6cbb\u7642\u4ecd\u4e0d\u6e05\u695a\u3002\u672c\u5be6\u9a57\u5ba4\u5c07\u63a2\u8a0e\u816b\u7624\u5fae\u74b0\u5883\u5982\u4f55\u900f\u904e\u8868\u89c0\u907a\u50b3\u5b78\u4f86\u8abf\u63a7LGR5\u9020\u91c9\u7d30\u80de\u7624\u5e79\u7d30\u80de\uff0c\u754c\u5b9a\u8abf\u63a7\u816b\u7624\u5e79\u7d30\u80de\u4e4b\u9593\u8cea\u7d30\u80de\u5206\u6ccc\u7d44\u7684\u4e3b\u8981\u6210\u5206\uff0c\u4e26\u900f\u904e\u55ae\u7d30\u80de\u5b9a\u5e8f\u7d50\u5408\u8868\u89c0\u57fa\u56e0\u7d44\u5b78\uff0c\u89e3\u6790\u9593\u8cea\u7d30\u80de\u5206\u6ccc\u7d44\u5c0d\u65bcLGR5\u5e79\u7d30\u80de\u7684\u4e8c\u50f9\u67d3\u8272\u8cea\u548c\u67d3\u8272\u8cea\u958b\u653e\u6027\u4e4b\u8abf\u63a7\uff0c\u4e26\u5efa\u7acb\u75c5\u4eba\u884d\u751f\u4e4b\u985e\u5668\u5b98\u548c\u52d5\u7269\u6a21\u578b\u4ee5\u52a9\u6df1\u5165\u4e86\u89e3\u9020\u91c9\u7d30\u80de\u7624\u767c\u75c5\u548c\u5fa9\u767c\u7684\u6a5f\u5236\u3002<\/p>\n\n\n\n

\u3010\u7814\u7a76\u8a08\u756b\u3011<\/p>\n\n\n\n

\u8a08\u756b\u57f7\u884c\u5e74\u9650<\/td>\u8a08\u756b\u540d\u7a31<\/td>\u8a08\u756b\u88dc\u52a9\u55ae\u4f4d<\/td>\u8a08\u756b\u64d4\u4efb\u5de5\u4f5c<\/td><\/tr>
2021\/11-2024\/07<\/td>\u816b\u7624\u5fae\u74b0\u5883\u5c0d\u9020\u91c9\u7d30\u80de\u7624LGR5\u985e\u5e79\u7d30\u80de\u4e4b\u8abf\u63a7 110-2314-B-A49A-553 -MY3<\/td>\u79d1\u6280\u90e8<\/td>\u4e3b\u6301\u4eba<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u767c\u8868\u8457\u4f5c(*: corresponding author)<\/strong><\/p>\n\n\n\n

\u671f\u520a\u8ad6\u6587<\/u><\/strong> (* <\/strong>\u901a\u8a0a\u4f5c\u8005<\/strong>; <\/strong>\uff03<\/strong> <\/strong>\u5171\u540c\u4f5c\u8005<\/strong>)<\/strong><\/p>\n\n\n\n

    \n
  1. TH Chang, R Shanti, Y Liang, J Zeng, S Shi, F Alawi, L Carrasco, Q Zhang, and A. D. Le. LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma. Cell death and disease. 2020 May 7;11(5):338. IF: 5.959<\/li>\n\n\n\n
  2. CM Jiang, QZ Zhang, R.M. Shanti, SH Shi, TH Chang, L Carrasco, F Alawi, A.D. Le. Mesenchymal Stromal Cell-derived IL-6 Promotes Epithelial-mesenchymal Transition and Acquisition of Epithelial Stem-like Cell Properties in Ameloblastoma Epithelial Cells. Stem Cells. 2017 Sep;35(9):2083-2094. IF: 5.614<\/li>\n\n\n\n
  3. QL Xu, A Furuhashi, QZ Zhang, CM Jiang, TH Chang, and A.D. Le. Induction of Salivary Gland\u2013Like Cells from Dental Follicle Epithelial Cells. J Dent Res. 2017 Aug;96(9):1035-1043. IF: 5.125<\/li>\n\n\n\n
  4. Ting-Han Chang, Da-Yo Yuh, Yung-Tsan Wu, Wan-Chien Cheng, Fu-Gong Lin, Yi-Shing Shieh, Earl Fu, Ren-Yeong Huang. The association between temporomandibular disorders and joint hypermobility syndrome: a nationwide population-based study. Clinical Oral Investigations. 2015;19:2123\u20132132. IF=2.453<\/li>\n\n\n\n
  5. Da-Yo Yuh, Ting-Han Chang, Ren-Yeong Huang, Wu-Chien Chien, Fu-Gong Lin, Earl Fu. The National-Scale Cohort Study on Bisphosphonate-Related Osteonecrosis of the Jaw in Taiwan. Journal of Dentistry. 2014;42:1343-1352. IF=3.28<\/li>\n<\/ol>\n\n\n\n

    \u7372\u734e\u9805\u76ee<\/strong><\/p>\n\n\n\n

    \u5e74\u5ea6<\/td>\u55ae\u4f4d<\/td>\u5f97\u734e\u7d00\u9304<\/td><\/tr>
    2017<\/td>\u7f8e\u570b\u8cd3\u5915\u6cd5\u5c3c\u4e9e\u5927\u5b78\u7259\u91ab\u5b78\u9662\u7259\u91ab\u5b78\u7814\u7a76\u5e74\u6703\u2014\u9752\u5e74\u7814\u7a76\u5b78\u8005\u7d44\u4e4b\u5b78\u8853\u6d77\u5831\u7af6\u8cfd<\/td>2018\u7f8e\u570b\u7259\u91ab\u5b78\u7814\u7a76\u8a0e\u8ad6\u6703\u7814\u7fd2\u734e<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

    \u5b78 \u6b77\uff1a \u7562\u696d\u5b78\u6821 \u570b\u5225 \u4e3b\u4fee\u7cfb\u5225 \u5b78\u4f4d \u7562\u696d\u5e74\u5ea6 \u8cd3\u5915\u6cd5\u5c3c\u4e9e\u5927\u5b78 \u7f8e\u570b \u7259\u91ab\u79d1\u5b78 \u535a\u58eb 2020 \u4e2d\u5c71\u91ab\u5b78\u5927 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2481","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/2481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2481"}],"version-history":[{"count":4,"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/2481\/revisions"}],"predecessor-version":[{"id":3188,"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/2481\/revisions\/3188"}],"wp:attachment":[{"href":"https:\/\/dod.nycu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}