{"id":2198,"date":"2021-09-09T07:01:16","date_gmt":"2021-09-09T07:01:16","guid":{"rendered":"https:\/\/dod.nycu.edu.tw\/?page_id=2198"},"modified":"2021-10-28T06:10:04","modified_gmt":"2021-10-28T06:10:04","slug":"%e6%9e%97%e6%80%a1%e5%bd%a3-%e5%89%af%e6%95%99%e6%8e%88-lin-yi-wen","status":"publish","type":"page","link":"https:\/\/dod.nycu.edu.tw\/?page_id=2198","title":{"rendered":"\u6797\u6021\u5f63 \u526f\u6559\u6388 (Lin, Yi-Wen)"},"content":{"rendered":"\n
\"\"<\/figure><\/div>\n\n\n

\u5b78\u6b77\uff1a<\/strong><\/h4>\n\n\n
\u7562\u696d\u5b78\u6821<\/strong><\/td>\u570b\u5225<\/strong><\/td>\u4e3b\u4fee\u7cfb\u5225<\/strong><\/td>\u5b78\u4f4d<\/strong><\/td>\u5e74\u5ea6<\/strong><\/td><\/tr>
\u570b\u9632\u91ab\u5b78\u9662<\/td> \u4e2d\u83ef\u6c11\u570b <\/td>\u751f\u547d\u79d1\u5b78\u7814\u7a76\u6240)<\/td>\u535a\u58eb<\/td>2007<\/td><\/tr>
\u570b\u7acb\u967d\u660e\u5927\u5b78 (\u73fe\u6539\u540d \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 ) <\/td>\u4e2d\u83ef\u6c11\u570b <\/td>\u53e3\u8154\u751f\u7269\u5b78\u7814\u7a76\u6240<\/td>\u78a9\u58eb<\/td>2000<\/td><\/tr>
\u570b\u7acb\u53f0\u5317\u8b77\u7406\u5b78\u9662<\/td>\u4e2d\u83ef\u6c11\u570b<\/td>\u8b77\u7406\u7cfb<\/td>\u5b78\u58eb<\/td>1998<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n

\u7d93\u6b77\uff1a<\/strong><\/h4>\n\n\n
\u670d\u52d9\u55ae\u4f4d<\/strong><\/td>\u670d\u52d9\u90e8\u9580<\/strong><\/td>\u8077\u7a31<\/strong><\/td>\u670d\u52d9\u671f\u9593<\/strong><\/td><\/tr>
\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78<\/td>\u53e3\u8154\u751f\u7269\u7814\u7a76\u6240<\/td>\u5c08\u4efb\u526f\u6559\u6388<\/td>2019.02-<\/td><\/tr>
\u570b\u7acb\u967d\u660e\u5927\u5b78 (\u73fe\u6539\u540d \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 ) <\/td>\u53e3\u8154\u751f\u7269\u7814\u7a76\u6240<\/td>\u517c\u4efb\u526f\u6559\u6388<\/td>2015.02-2019.01<\/td><\/tr>
\u570b\u7acb\u967d\u660e\u5927\u5b78 (\u73fe\u6539\u540d \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 ) <\/td>\u53e3\u8154\u751f\u7269\u7814\u7a76\u6240<\/td>\u517c\u4efb\u52a9\u7406\u6559\u6388<\/td>2010.08-2015.01<\/td><\/tr>
\u570b\u9632\u91ab\u5b78\u9662<\/td>\u91ab\u5b78\u7cfb\u5fc3\u81df\u8840\u7ba1\u5916\u79d1<\/td>\u91ab\u5b78\u7814\u7a76\u54e1<\/td>2010.02-2019.01<\/td><\/tr>
\u8f14\u4ec1\u5927\u5b78\u91ab\u5b78\u9662<\/td>\u57fa\u790e\u91ab\u5b78\u7814\u7a76\u6240<\/td>\u5c08\u4efb\u52a9\u7406\u6559\u6388<\/td>2009.09-2010.01<\/td><\/tr>
\u4e2d\u592e\u7814\u7a76\u9662 <\/td>\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6240<\/td>\u535a\u58eb\u5f8c\u7814\u7a76\u54e1<\/td>2007.08-2009.08<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n

\u5c08\u9577\uff1a\u7d30\u80de\u751f\u7269\u5b78\u3001\u5206\u5b50\u751f\u7269\u5b78\u3001\u5be6\u9a57\u52d5\u7269\u5b78<\/strong><\/p>\n\n\n

\u806f\u7d61\u96fb\u8a71<\/strong>\uff1a(02) 2826-7915<\/p>\n\n\n\n

\u50b3\u771f\u96fb\u8a71<\/strong>\uff1a(02) 2826-4053<\/p>\n\n\n\n

\u96fb\u5b50\u90f5\u4ef6<\/strong>\uff1aywlin@nycu.edu.tw<\/a><\/a><\/p>\n\n\n\n

\u5be6\u9a57\u5ba4\u4ecb\u7d39\u5f71\u7247\u9023\u7d50\uff1a  \u7db2\u5740\u4e00<\/a>    <\/strong><\/p>\n\n\n

\u7814\u7a76\u65b9\u5411<\/h4>\n

1. \u8840\u6813\u8abf\u7bc0\u56e0\u5b50(thrombomodulin) \u5728\u55ae\u6838\u7403\u7d30\u80de\u4e4b\u529f\u80fd\u53ca\u5176\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u95dc\u4fc2<\/p>\n

\u8840\u6813\u8abf\u7bc0\u56e0\u5b50thrombomodulin (TM) \u70ba\u4e00\u7a2e\u7b2cI\u578b\u4e4b\u7cd6\u57fa\u5316\u8de8\u819c\u86cb\u767d\uff0c\u5176\u6700\u65e9\u88ab\u767c\u73fe\u5728\u5167\u76ae\u7d30\u80de\u4e0a\u5927\u91cf\u8868\u73fe\uff0c\u5176\u53ef\u85c9\u7531\u589e\u52a0\u51dd\u8840\u9176\/\u86cb\u767dC\u7684\u6d3b\u5316\u800c\u9054\u5230\u6297\u51dd\u8840\u4e4b\u4f5c\u7528\u3002\u9664\u6b64\u5916\uff0cTM\u5728\u89d2\u8cea\u7d30\u80de\u3001\u5de8\u6838\u7d30\u80de\u3001\u8840\u5c0f\u677f\u3001\u55ae\u6838\u7d30\u80de\u53ca\u5e73\u6ed1\u808c\u7d30\u80de\u4e0a\u4e5f\u88ab\u5831\u5c0e\u5177\u6709\u8868\u73fe\u60c5\u5f62\uff0c\u9019\u4ee3\u8868TM\u5728\u5176\u4ed6\u7d30\u80de\u61c9\u5177\u6297\u51dd\u8840\u4ee5\u5916\u4e4b\u7d30\u80de\u529f\u80fd\u3002\u6211\u7684\u7814\u7a76\u91cd\u9ede\u5728\u63a2\u8a0e\u8840\u6813\u8abf\u7bc0\u86cb\u767d\u5728\u55ae\u6838\u7403\u7d30\u80de\u4e4b\u5206\u5316\u529f\u80fd\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272\u4ee5\u53ca\u5b83\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u767c\u751f\u7684\u76f8\u95dc\u6027\u3002\u6211\u5011\u5148\u524d\u7684\u7814\u7a76\u7d50\u679c\u6307\u51fa\u55ae\u6838\u7403\u7d30\u80de\u85c9\u7531TM\u7684\u5927\u91cf\u8868\u73fe\u53ca\u8207PKC\u03b4\u76f8\u4e92\u4f5c\u7528\u800c\u8abf\u63a7\u5176\u5206\u5316\u70ba\u5de8\u566c\u7d30\u80de\uff0c\u9032\u800c\u4fc3\u9032\u7ca5\u6a23\u52d5\u8108\u786c\u5316\u7684\u5f62\u6210\u3002\u6b64\u5916\uff0c\u6211\u5011\u7684\u81e8\u5e8a\u7814\u7a76\u4e5f\u767c\u73fe\u8840\u6813\u8abf\u7bc0\u56e0\u5b50\u7684\u57fa\u56e0\u8b8a\u7570(genetic variation  C1418T) \u4e5f\u8207\u5fc3\u81df\u79fb\u690d\u5f8cCAV (Cardiac Allograft Vasculopathy; \u5fc3\u81df\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\u5f8c\u4e4b\u8840\u7ba1\u75c5\u8b8a) \u7684\u767c\u751f\u56b4\u91cd\u60c5\u5f62\u6709\u95dc\u3002C1418T\u8a98\u5c0e\u7684\u55ae\u6838\u7403\u7d30\u80de\u529f\u80fd\u969c\u7919\u53ca\u5c0e\u81f4\u56b4\u91cdCAV\u767c\u751f\u60c5\u5f62\u7684\u5206\u5b50\u6a5f\u5236\u5c07\u5728\u672a\u4f86\u9032\u884c\u66f4\u9032\u4e00\u6b65\u4e4b\u63a2\u8a0e\u3002<\/p>\n

2. \u7259\u5468\u75c5\u8207\u7cfb\u7d71\u6027\u75be\u75c5\u7684\u76f8\u95dc\u6027<\/p>\n

Porphyromonas gingivalis<\/em> (P. gingivalis) <\/em>\u662f\u4e00\u7a2e\u5c0e\u81f4\u7259\u5468\u7d44\u7e54\u7834\u58de\u7684\u7d30\u83cc\u3002\u5148\u524d\u7814\u7a76\u6307\u51fa\uff0c\u4f86\u81eaP. gingivalis<\/em> \u4e4bGroEL\u86cb\u767d\u5177\u6709\u5c0e\u81f4\u5168\u8eab\u6027\u767c\u708e\u53cd\u61c9\u7684\u751f\u7269\u6d3b\u6027\u3002\u8fd1\u5e74\u4f86\uff0c\u9678\u7e8c\u6709\u8a31\u591a\u7684\u7814\u7a76\u6307\u51fa\u7259\u5468\u75c5\u8207\u7cfb\u7d71\u6027\u75be\u75c5\uff0c\u5982\u52d5\u8108\u7ca5\u6a23\u786c\u5316\uff0c\u7cd6\u5c3f\u75c5\uff0c\u80ba\u90e8\u75be\u75c5\uff0c\u65e9\u7522\u548c\u764c\u75c7\u7684\u767c\u751f\u90fd\u5177\u6709\u76f8\u95dc\u3002\u6211\u5011\u5148\u524d\u7684\u7814\u7a76\u7d50\u679c\u767c\u73feP. gingivalis<\/em> \u4e4bGroEL\u86cb\u767d\u6703\u85c9\u7531\u4fc3\u9032\u8840\u7ba1\u65b0\u751f\u4f5c\u7528\u800c\u5c0e\u81f4\u816b\u7624\u4e4b\u52a0\u901f\u751f\u9577\u3002\u7259\u5468\u75c5\u8207\u5168\u8eab\u6027\u7cfb\u7d71\u6027\u75be\u75c5\u4e4b\u76f8\u95dc\u6027\u53caP. gingivalis<\/em> \u4e4bGroEL\u86cb\u767d\u8a98\u5c0e\u7684\u7cfb\u7d71\u6027\u75be\u75c5\u7684\u4f5c\u7528\u5206\u5b50\u6a5f\u5236\u5c07\u5728\u672a\u4f86\u9032\u884c\u66f4\u9032\u4e00\u6b65\u4e4b\u63a2\u8a0e\u3002<\/p>\n

\u7814\u7a76\u8a08\u756b\uff085<\/span><\/span>\u5e74\u5167\uff09<\/h4>\n\n\n
\u5e74\u5ea6<\/strong><\/td>\u8a08\u756b\u540d\u7a31<\/strong><\/td>\u8a08\u756b\u5167\u64d4\u4efb\u4e4b\u5de5\u4f5c<\/strong><\/td>\u57f7\u884c\u671f\u9593<\/strong><\/td>\u55ae\u4f4d<\/strong><\/td><\/tr>
2021<\/td>Porphyromonas gingivalis \u611f\u67d3\u5c0d\u7570\u9ad4\u5668\u5b98\u79fb\u690d\u5f8c\u8840\u7ba1\u75c5\u8b8a\u4e4b\u5f71\u97ff(110-2314-B-016-038-MY3)<\/td>\u5171\u540c\u4e3b\u6301\u4eba<\/td>2021\/08\/01~
2024\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr>
2021<\/td>\u7259\u5468\u81f4\u75c5\u83cc\u52a0\u5287\u8179\u4e3b\u52d5\u8108\u7624\u751f\u6210\u7684\u6a5f\u5236\u8207\u958b\u767c\u6a19\u9776\u6cbb\u7642\u7684\u53ef\u884c\u6027\u7814\u7a76 (110-2320-B-038-032-MY3)<\/td>\u5171\u540c\u4e3b\u6301\u4eba<\/td>2021\/08\/01~
2024\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr>
2021<\/td>Connexin 43\u5728\u4e59\u578b\u5229\u9209\u80dc\u80bd\u6240\u8a98\u767c\u4e4b\u5fc3\u623f\u7e96\u7dad\u5316\u4e2d\u6240\u626e\u6f14\u4e4b\u89d2\u8272(110-2314-B-016-049-MY2)<\/td>\u5171\u540c\u4e3b\u6301\u4eba<\/td>2021\/08\/01~
2023\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr>
2021<\/td>\u96fb\u6f3f\u6d3b\u5316\u5c0f\u5206\u5b50\u6c34\u7528\u65bc\u9810\u9632\u5668\u5b98\u79fb\u690d\u5f8c\u8840\u7ba1\u75c5\u8b8a\u4e4b\u53ef\u884c\u6027\u7814\u7a76(VTA110-T-6-1)<\/td>\u5171\u540c\u4e3b\u6301\u4eba<\/td>2021\/01\/01~
2021\/12\/31<\/td>		\u69ae\u7e3d\u3001\u4e09\u7e3d\u3001\u53ca\u4e2d\u7814\u9662\u5408\u4f5c\u8a08\u756b<\/td><\/tr>
2021<\/td>\u55ae\u7d14\u76b0\u75b9\u75c5\u6bd2\u8207\u53e3\u8154\u7d30\u83cc\u7684\u611f\u67d3\u5c0d\u65bc\u5de8\u566c\u7d30\u80de\u529f\u80fd\u7684\u5f71\u97ff(109-2314-B-010-008-MY2)<\/td>\u5171\u540c\u4e3b\u6301\u4eba<\/td>2020\/08\/01~
2022\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr>
2021<\/td>\u63a2\u8a0e\u7259\u5468\u81f4\u75c5\u83ccAggregatibacter actinomycetemcomitans\u589e\u52a0\u7570\u9ad4\u5668\u5b98\u79fb\u690d\u5f8c\u8840\u7ba1\u75c5\u8b8a\u767c\u751f\u4e4b\u6a5f\u5236(108\u5e74\u79d1\u6280\u90e8\u5c08\u984c\u7814\u7a76\u8a08\u756b\u4e4b\u5ef6\u7e8c) (109-2314-B-016-048-)<\/td>\u5171\u540c\u4e3b\u6301\u4eba<\/td>2020\/08\/01~
2021\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr>
2020<\/td>\u63a2\u8a0e\u7259\u5468\u81f4\u75c5\u83ccAggregatibacter actinomycetemcomitans\u5c0d\u5fc3\u81df\u79fb\u690d\u5f8c\u8840\u7ba1\u75c5\u8b8a\u767c\u751f\u4e4b\u5f71\u97ff\u53ca\u5176\u8abf\u7bc0\u6a5f\u5236\u4e4b\u63a2\u8a0e(108-2314-B-016-051-)<\/td>\u5171\u540c\u4e3b\u6301\u4eba <\/td>2019\/08\/01~
2020\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr>
2020<\/td>\u4e59\u578b\u5229\u9209\u80dc\u80bd\u5c0d\u5fc3\u623f\u7e96\u7dad\u5316\u4e4b\u5f71\u97ff\u53ca\u5176\u6a5f\u5236\u4e4b\u63a2\u8a0e(106-2314-B-016-037-MY3)<\/td>\u5171\u540c\u4e3b\u6301\u4eba <\/td>2017\/08\/01~
2020\/07\/31<\/td>		\u79d1\u6280\u90e8<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n

\u671f\u520a\u8ad6\u6587<\/strong><\/h4>\n
    \n
  1. Tsai CS, Lin FY, Liu YC, Lin YW<\/strong>, Tsai YT, Huang CY, Lin SJ, Li CY, Lin CY, Tseng HT and Shih CM. Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model. Polymers (Basel). 2021;13.<\/li>\n
  2. Lin HH, Lin YW<\/strong>, Wu CY, Hsiao FP, Lai YL and Hung SL. Stimulatory effects of Porphyromonas gingivalis GroEL protein on interleukin-6 and interleukin-8 in human osteoblasts. J Formos Med Assoc. 2021;120:150-156.<\/li>\n
  3. Lin FY, Lin YW<\/strong>, Shih CM, Lin SJ, Tung YT, Li CY, Chen YH, Lin CY, Tsai YT and Huang CY. A Novel Relative High-Density Lipoprotein Index to Predict the Structural Changes in High-Density Lipoprotein and Its Ability to Inhibit Endothelial-Mesenchymal Transition. Int J Mol Sci. 2021;22.<\/li>\n
  4. Lin FY, Shih CM, Huang CY, Tsai YT, Loh SH, Li CY, Lin CY, Lin YW<\/strong>* and Tsai CS*. Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats. Cardiovasc Drugs Ther. 2020. (\u5171\u540c\u8cac\u4efb\u4f5c\u8005)<\/strong><\/li>\n
  5. Tsai YT, Lin FY, Lin CS, Loh SH, Li CY, Lin CY, Lin YW<\/strong>* and Tsai CS*. B-type natriuretic peptide enhances fibrotic effects via matrix metalloproteinase-2 expression in the mouse atrium in vivo and in human atrial myofibroblasts in vitro. Transl Res. 2019;208:30-46. (\u5171\u540c\u8cac\u4efb\u4f5c\u8005)<\/strong><\/li>\n
  6. Shih CM, Lin FY, Yeh JS, Lin YW<\/strong>, Loh SH, Tsao NW, Nakagami H, Morishita R, Sawamura T, Li CY, Lin CY and Huang CY. Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality. Transl Res. 2019;205:17-32.<\/li>\n
  7. Chen YC, Lin FY, Lin YW<\/strong>, Cheng SM, Lin RH, Chuang CL, Sheu JS, Chen SM, Chang CC and Tsai CS. DAPT Plus Cilostazol is Better Than Traditional DAPT or Aspirin Plus Ticagrelor as Elective PCI for Intermediate-to-Highly Complex Cases: Prospective, Randomized, PRU-Based Study in Taiwan. Am J Cardiovasc Drugs. 2019;19:75-86.<\/li>\n
  8. Chen YC, Lin FY, Lin YW<\/strong>, Cheng SM, Chang CC, Lin RH, Chuang CL, Sheu JS, Chen SM and Tsai CS. Platelet MicroRNA 365-3p Expression Correlates with High On-treatment Platelet Reactivity in Coronary Artery Disease Patients. Cardiovasc Drugs Ther. 2019;33:129-137.<\/li>\n
  9. Lin YW<\/strong>, Huang CY, Shih CM, Tsai YT, Lin CS, Lin CY, Li CY, Loh SH, Lin CY, Lin FY and Tsai CS. Eotaxin-2 induces monocytic apoptosis in patients who have undergone coronary artery bypass surgery and in THP-1 cells in vitro regulated by thrombomodulin. Am J Transl Res. 2018;10:3133-3149. (\u7b2c\u4e00\u4f5c\u8005)<\/strong><\/li>\n
  10. Pai CC, Lin YW<\/strong>, Tsai YT, Loh SH, Lin CY, Lin CS, Lin YC, Ke HY, Lin FY and Tsai CS. A Thrombomodulin Gene Polymorphism (C1418T) Is Associated with Early Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Conventional Cardiopulmonary Bypass during Hospitalization. Medicines (Basel). 2017;4.<\/li>\n
  11.  Lu HY, Huang CY, Shih CM, Lin YW<\/strong>, Tsai CS, Lin FY and Shih CC. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. J Vasc Surg. 2017;66:1217-1226 e1.<\/li>\n
  12. Tsai CS*, Lin YW*<\/strong>, Huang CY, Shih CM, Tsai YT, Tsao NW, Lin CS, Shih CC, Jeng H and Lin FY. Thrombomodulin regulates monocye differentiation via PKCdelta and ERK1\/2 pathway in vitro and in atherosclerotic artery. SciRep. 2016;6:38421. (\u5171\u540c\u7b2c\u4e00\u4f5c\u8005)<\/strong><\/li>\n
  13. Tsai CS, Huang CY, Chen CH, Lin YW<\/strong>, Shih CM, Tsao NW, Chiang KH, Lee CY, Jeng H and Lin FY. Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo. Am J Transl Res. 2016;8:5338-5353.<\/li>\n
  14. Lu HY, Huang CY, Shih CM, Lin YW<\/strong>, Tsai CS, Lin FY and Shih CC. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. J Vasc Surg. 2016.<\/li>\n
  15. Huang CY, Shih CM, Tsao NW, Lin YW<\/strong>, Shih CC, Chiang KH, Shyue SK, Chang YJ, Hsieh CK and Lin FY. The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression. Am J Transl Res. 2016;8:384-404.<\/li>\n<\/ol>\n\n\n
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