國立陽明交通大學牙醫學系

National Yang Ming Chiao Tung University Department of Dentistry

YANG Cheng-Chieh

Name
YANG Cheng-Chieh

Qualifications
DDS (National Yang Ming University, TAIWAN)
Ph.D. (University of Texas, MD Anderson Cancer Center, USA)
Certificate in Oral & Maxillofacial Surgery (TAIWAN)

Appointment Status
Professor and Department Chair

Discipline
Oral & Maxillofacial Surgery, Cancer Biology

Membership of Associated Professional Bodies
Asian Association of Oral & Maxillofacial Surgeons
Association of Oral & Maxillofacial Surgeons, Taiwan                             

Research Interests
Epigenetic changes in oral carcinogenesis.
ROS effects on oral carcinogenesis.
Adoptive T cell immunotherapy for oral cancer.

Awards
2001, 2002 Annual outstanding teaching award, Residents group, Taipei-VGH
2002,2003 Best article award, Annual Congress of Taiwan Association of Oral and Maxillofacial Surgeons.
2004-2008 4-year scholarship of abroad doctorate program of Yen Tjing Ling medical foundation, University of Texas, MD Anderson Cancer Center
2012 Outstanding Teacher of National Yang-Ming University
2016 2nd prize article award of 12th Asian Congress on Oral and Maxillofacial Surgery
2016 Annual outstanding teaching award, Attending group, Taipei-VGH
2017 Chairman of ROC Head and Neck Cancer Care Association
2018 Significant achievement in the exhibition of Healthcare EXPO.Taiwan
2018 Annual outstanding teaching attending award, Taipei-VGH

Publications

  1. Tu HF, Chen MY, Lai JC, Chen YL, Wong YW, Yang CC, Chen HY, Hsia SM, Shih YH, Shieh TM. Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression. Head Neck, [Epub ahead of print].
  2. Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH, Chang KW, Lin SC. miR-125b suppresses oral oncogenicity by targeting the antioxidative gene PRXL2A. Redox Biology, [Epub ahead of print].
  3. Peng SY, Tu HF, Yang CC, Wu CH, Liu CJ, Chang KW, Lin SC. miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. Int J Cancer, 143(11), 2892-2904.
  4. Lin JS, Sun FJ, Lin PY, Chang KW, Yang CC, Liu CJ. Clinicopathological and prognostic significance of preoperative serum epidermal growth factor levels in patients with oral squamous cell carcinoma. Int J Oral Maxillofac Surg, 47(10), 1236-42.
  5. Yang CC, Chang KW. Eicosanoids and HB-EGF/EGFR in cancer. Cancer Metastasis Review, 37(2-3), 385-95.
  6. Chang CW, Chen YS, Tsay YG, Han CL, Chen YJ, Yang CC, Hung KF, Lin CH, Huang TY, Kao SY, Lee TC, Lo JF. ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells. Cell death & disease, 9(2), 194-208.
  7. Lim E, Wu CH, Moi SH, Lui MT, Yang CH, Yang CC. The expression of transglutaminase 2 (TG-2) in oral squamous cell carcinoma and its clinical significance. Journal of the Chinses Medical Association, 80(8), 515-20.
  8. Lim E, Kuo CC, Tu HF, Yang CC. The prognosis outcome of oral squamous cell carcinoma using HIF-2α. Journal of the Chinese Medical Association, 80(10), 651-56.
  9. Yu EH, Tu HF, Wu CH, Yang CC, Chang KW. MicroRNA-21 promotes perineural invasion and impacts survival in patients with oral carcinoma. Journal of the Chinese Medical Association, 80(6), 383-88.
  10. Yeh CF, Li WY, Chu PY, Kao SY, Chen YW, Lee TL, Hsu YB, Yang CC, Tai SK. Pretreatment pain predicts perineural invasion in oral squamous cell carcinoma: A prospective study. Oral Oncology, 61, 115-9.
  11. Chen YF, Yang CC, Kao SY, Liu CJ, Lin SC, Chang KW. MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity. Cancer Research, 76(16), 4872-86.
  12. Ko HW, Lee HH, Huo L, Xia W, Yang CC, Hsu JL, Li LY, Lai CC, Chan LC, Cheng CC, Labaff AM, Liao HW, Lim SO, Li CW, Wei Y, Nie L, Yamaguchi H, Hung MC. GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget, 7(35), 57131-44.
  13. Lu WC, Liu CJ, Tu HF, Chung YT, Yang CC, Kao SY, Chang KW, Lin SC. miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma. Oncotarget, 7(35), 57254-57267.
  14. Yang CC, Tu HF, Wu CH, Chang HC, Chiang WF, Shih NC, Lee YS, Kao SY, Chang KW. Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC. Oral Oncology, 56, 54-61.
  15. Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, Chan LC, Yao J, Kleer CG, Hortobagyi GN, Hung MC. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. American Journal of Translational Research, 7(6), 1009-20.
  16. Tseng SH, Yang CC, Yu EH, Chang C, Lee YS, Liu CJ, Chang KW, Lin SC. K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression. Int J Cancer, 136(6), 1263-75.
  17. Chang CW, Chen YS, Chou SH, Han CL, Chen YJ, Yang CC, Huang CY, Lo JF. Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity. Cancer Research, 74(21), 6291-305.
  18. Lu WC, Kao SY, Yang CC, Tu HF, Wu CH, Chang KW, Lin SC. EGF up-regulates miR-31 through the C/EBPβ signal cascade in oral carcinoma. PLoS One, 9(9), e108049.
  19. Hung PS, Tu HF, Kao SY, Yang CC, Liu CJ, Huang TY, Chang KW, Lin SC. miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes. Carcinogenesis, 35(5),1162-71.
  20. Yu EH, Lui MT, Tu HF, Wu CH, Lo WL, Yang CC, Chang KW, Kao SY. Oral carcinoma with perineural invasion has higher nerve growth factor expression and worse prognosis. Oral Diseases, 20(3), 268-74.
  21. Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MC. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene, 33(6), 756-70.
  22. Hung PS, Liu CJ, Chou CS, Kao SY, Yang CC, Chang KW, Chiu TH, Lin SC. miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes. PLoS One, 8(11): e79926.
  23. Chu TH, Yang CC, Liu CJ, Lui MT, Lin SC, Chang KW. miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII. Cancer Lett, 337(1), 115-124.
  24. Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, Hung MC. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Molecular Medicine, 5(4), 531-47.
  25. Tu HF, Liu CJ, Chang CL, Wang PW, Kao SY, Yang CC, Yu EH, Lin SC, Chang KW. The association between genetic polymorphism and the processing efficiency of miR-149 affects the prognosis of patients with head and neck squamous cell carcinoma. PLoS One, 7(12), e51606, 1-10.
  26. Chang KW, Chu TH, Gong NR, Chiang WF, Yang CC, Liu CJ, Wu CH, Lin SC. miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma. ORAL DISEASES, 19(6), 611-9.
  27. Liu CJ, Lin SC, Yang CC, Cheng HW, Chang KW. Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head Neck, 34(2), 219-24.
  28. Tseng YH, Chang KW, Yang CC, Liu CJ, Kao SY, Liu TY, Lin SC. Association between areca-stimulated vimentin expression and the progression of head and neck cancers. Head Neck, 34(2), 245-53.
  29. Yang CC, Hung PS, Wang PW, Liu CJ, Chu TH, Cheng HW, Lin SC. miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 40(5), 397-404.
  30. Tseng YH, Yang CC, Lin SC, Cheng CC, Lin SH, Liu CJ, Chang KW. Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma. J Oral Patho Med, 40(2), 160-6.
  31. Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol, 13(1), 87-94.

Contact
Email Address : ccyang1124@nycu.edu.tw